Analytical instruments, assemblies, and methods

• US 9,347,920 B2
• Filed: 02/09/2015
• Issued: 05/24/2016
• Est. Priority Date: 06/15/2004
• Status: Active Grant

• Current Assignee: Flir Detection, Inc. (Teledyne Technologies Incorporated)
• Original Assignee: Flir Detection, Inc. (Teledyne Technologies Incorporated)
• Inventors: Patterson, Garth E., Barket, Dennis Jr., Gregory, Mark, Springston, Jason
• Primary Examiner(s): MASKELL, MICHAEL P
• Application Number:
  US14/617,258
• Publication Number:
  US 20150177201A1
• Time in Patent Office: 470 Days
• Field of Search: 250/281, 250/282, 250/288, 250/289, 250/290
• US Class Current: 1/1
• CPC Class Codes: G01N 1/405 by adsorption or absorption
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 30/06 Preparation
• CPC Class Codes: G01N 30/7206 interfaced to gas chromatograph interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04
• CPC Class Codes: G01N 30/722 through a gas permeable barrier (membranes, porous layers)
• CPC Class Codes: H01J 49/0022 Portable spectrometers, e.g. devices comprising independent power supply, constructional details relating to portability small scale devices per se H01J49/0013 and H01J49/0018
• CPC Class Codes: H01J 49/02 Details

Abstract

Person-portable mass analysis instrumentation configured to perform multidimensional mass analysis is provided. Mass analysis instrumentation can include a housing encompassing components of the instrumentation with the housing of the instrumentation defining a space having a volume of equal to or less than about 100,000 cm³. Instrument assemblies are also provided that can include a housing coupled to an instrument component isolation assembly, wherein the component isolation assembly is isolated from an environment exterior to the housing. Exemplary instrument assemblies can include at least first and second components configured to provide analysis with a housing of the instrument at least partially encompassing the first and second components and the first component being rigidly affixed to the housing. An isolation assembly can also be provided that is rigidly affixed to the second component with the isolation assembly being isolated from received inputs of the housing.

Claims

1. A mass analysis instrument comprising:

a housing encompassing components of the instrument, the housing defining a space having a volume of equal to or less than about 100,000 cm³, the components within the housing comprising;

a sample inlet component configured to one or both couple with at least one sampler external to the housing and/or receive sample directly;

a gas chromatography sample preparation component operatively coupled to the sample inlet component;

an ionization component operatively coupled to the gas chromatography sample preparation component;

an ion trap component operatively coupled to the ionization component, the ion trap component comprising a cylindrical ion trap or a linear ion trap;

an ion detection component operatively coupled to the ion trap component, the ion detection component comprising an electron multiplier having a conversion dynode;

a vacuum chamber housing at least the ionization component, the ion trap component and the ion detection component; and

a processing and control component operatively coupled to one or more of the inlet component, the sample preparation component, the ionization component, the ion trap component and/or the ion detection component.

2. The instrument of claim 1 wherein the sample inlet component comprises a syringe port, and wherein the sample inlet component is operatively configured to receive a sample and provide the sample to the sample preparation component.

3. The instrument of claim 1 wherein the instrument is configured to perform multidimensional mass analysis.

4. The instrument of claim 1 wherein the processing and control component is configured to provide mass analysis parameters to the ion trap component.

5. The instrument of claim 4 wherein the mass analysis parameters include waveforms.

6. The instrument of claim 1 wherein the inlet component is configured to receive gas phase samples directly into the inlet component when coupled to an external sampling device.

7. The instrument of claim 1 wherein the inlet component is configured to receive liquid phase samples directly into the inlet component when coupled to an external sampling device.

8. The instrument of claim 1 wherein the inlet component is configured to receive gas and liquid phase samples directly into the inlet component when coupled to an external sampling device.

9. The instrument of claim 1 wherein the inlet component is configured to receive gas, liquid, and solid phase samples directly into the inlet component.

10. The instrument of claim 1 wherein the inlet component is configured to sample air continuously.

11. The instrument of claim 1 wherein the ionization component is a chemical ionization component.

12. The instrument of claim 1 further comprising another ion trap component operatively aligned between the ionization component and the ion detection component.

13. The instrument of claim 1 wherein the ion detection component is configured to perform dual polarity ion detection.

14. A portable gas chromatography and mass analysis instrument comprising:

a sample inlet component;

a gas chromatography sample preparation component operatively coupled to the sample inlet component;

an ionization component operatively coupled to the gas chromatography sample preparation component;

an ion trap component operatively coupled to the ionization component;

an ion detection component operatively coupled to the ion trap component, the ion detection component comprising an electron multiplier having a conversion dynode;

a vacuum chamber housing at least the ionization component, the ion trap component and the ion detection component; and

a processing and control component operatively coupled to one or more of the sample inlet component, the sample preparation component, the ionization component, the ion trap component and/or the ion detection component.

15. The portable gas chromatography and mass analysis instrument of claim 14 wherein the components of claim 14 are confined within a housing defining a space having a volume of equal to or less than about 100,000 cm³.

16. The portable gas chromatography and mass analysis instrument of claim 14 wherein the sample inlet component is configured to one or both couple with at least one sampler external to the housing and/or receive sample directly.

17. The portable gas chromatography and mass analysis instrument of claim 14 wherein the ion trap component comprises a cylindrical ion trap or a linear ion trap.

18. The portable gas chromatography and mass analysis instrument of claim 14 further comprising another ion trap component operatively aligned between the ionization component and the ion detection component.