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Method of assessing risk of multiple births in infertility treatments

  • US 9,348,972 B2
  • Filed: 07/13/2011
  • Issued: 05/24/2016
  • Est. Priority Date: 07/13/2010
  • Status: Active Grant
First Claim
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1. A method comprising:

  • (a) selecting data specific to a female human patient at pre-in vitro fertilization (pre-IVF) or at a pre-embryo transfer (pre-ET) step of an IVF treatment, wherein the data is selected from the group consisting of the patient'"'"'s age, the patient'"'"'s ethnicity, the patient'"'"'s medical and reproductive history, the patient'"'"'s male partner'"'"'s age, the patient'"'"'s male partner'"'"'s ethnicity, the patient'"'"'s male partner'"'"'s medical and reproductive history, the patient'"'"'s response to hormonal control agents, number of oocytes obtained from the patient, number of embryos obtained from the patient, oocyte quality, egg quality, sperm quality, fertilization quality, embryo quality, embryo developmental parameters, embryology laboratory protocols, infertility treatment protocols, and combinations thereof;

    (b) entering the data of step (a) into a software application that analyzes data to predict the likelihood that the pre-IVF or pre-ET-female human patient will experience a multiple birth event, wherein the software application hosts at least one algorithm and is run in real time or in batches and the prediction of the multiple birth event triggers, precedes, or qualifies an embryo viability testing event; and

    (c) conducting an embryo viability test to select viable embryos for transfer to the female human patient, wherein the selection of the viable embryos transferred to the female human patient is based upon the multiple birth prediction of step (b).

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