Optimizing therapy outcomes for peritoneal dialysis
First Claim
1. A method for accomplishing automated peritoneal dialysis, comprising:
- administering a peritoneal equilibration test (“
PET”
) to a patient;
determining and recording a patient status as a result of the PET test, the patient status selected from the group consisting of a high transporter, average transporter, low transporter, and combinations thereof;
calculating a peritoneal dialysis dwell time based on the patient status and at least one peritoneal dialysis therapy outcome, wherein the dwell time optimizes the at least one peritoneal dialysis therapy outcome for the patient, said calculating including (i) averaging an optimized dwell time for a plurality of peritoneal dialysis therapy outcomes or (ii) using a weighted average of an optimized dwell time of each of the plurality of peritoneal dialysis therapy outcomes; and
performing at least one treatment cycle with the calculated peritoneal dialysis dwell time using an automated peritoneal dialysis machine.
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Accused Products
Abstract
Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.
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Citations
22 Claims
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1. A method for accomplishing automated peritoneal dialysis, comprising:
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administering a peritoneal equilibration test (“
PET”
) to a patient;determining and recording a patient status as a result of the PET test, the patient status selected from the group consisting of a high transporter, average transporter, low transporter, and combinations thereof; calculating a peritoneal dialysis dwell time based on the patient status and at least one peritoneal dialysis therapy outcome, wherein the dwell time optimizes the at least one peritoneal dialysis therapy outcome for the patient, said calculating including (i) averaging an optimized dwell time for a plurality of peritoneal dialysis therapy outcomes or (ii) using a weighted average of an optimized dwell time of each of the plurality of peritoneal dialysis therapy outcomes; and performing at least one treatment cycle with the calculated peritoneal dialysis dwell time using an automated peritoneal dialysis machine. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for accomplishing automated peritoneal dialysis, comprising:
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determining peritoneal transport properties of a patient; determining a classification of the peritoneal transport properties of the patient; calculating a peritoneal dialysis dwell time based on the classification, a plurality of peritoneal dialysis input parameters, and at least one desired peritoneal dialysis therapy outcome, wherein the dwell time is calculated to maximize the at least one desired peritoneal dialysis therapy outcome, said calculating including (i) averaging an optimized dwell time for a plurality of peritoneal dialysis therapy outcomes or (ii) using a weighted average of an optimized dwell time of each of the plurality of peritoneal dialysis therapy outcomes; and performing at least one treatment cycle with the calculated peritoneal dialysis dwell time using an automated peritoneal dialysis machine. - View Dependent Claims (8, 9, 10, 11)
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12. A system for calculating a peritoneal dialysis dwell time and conducting automated peritoneal dialysis, the system comprising:
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a processor for operating an automated peritoneal dialysis machine; a memory of the processor or a memory accessible to the processor, the memory storing a look-up table containing peritoneal dialysis input parameters, peritoneal dialysis therapy outcomes, and peritoneal dialysis dwell times corresponding to the input parameters and dwell times; and a software program stored in the memory of the processor or the memory accessible to the processor for receiving a selection or an input of at least one desired therapy outcome of a patient and calculating a dwell time for the patient for optimizing the at least one peritoneal dialysis therapy outcome for the patient, wherein the dwell time is calculated by (i) averaging an optimized dwell time for a plurality of peritoneal dialysis therapy outcomes or (ii) using a weighted average of an optimized dwell time of each of the plurality of peritoneal dialysis therapy outcomes. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A computer program embodied on a computer readable medium for calculating a peritoneal dialysis dwell time, comprising:
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a code segment for accessing data of a correspondence between a plurality of peritoneal dialysis input parameters, a plurality of peritoneal dialysis therapy outcomes, and a plurality of peritoneal dialysis dwell times; a code segment that allows a user to input or to select at least one peritoneal dialysis input parameter from the plurality of peritoneal dialysis input parameters and at least one desired therapy outcome; a code segment that receives an indication of the at least one input parameter and at least one desired therapy outcome selected by the user; a code segment that calculates a dwell time corresponding to the at least one desired therapy outcome selected by the user, said code configured to calculate the dwell time by (i) averaging an optimized dwell time for a plurality of peritoneal dialysis therapy outcomes or (ii) using a weighted average of an optimized dwell time of each of the plurality of peritoneal dialysis therapy outcomes; and a code segment that inputs the dwell time to an automated peritoneal dialysis machine. - View Dependent Claims (20, 21)
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22. An automated peritoneal dialysis system, comprising:
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a dialysis cassette and a housing suitable for receiving the cassette, the cassette including at least one pump for pumping dialysis fluid to and from a patient; a microcontroller suitable for operating the automated peritoneal dialysis system; a memory of the microcontroller or accessible to the microcontroller, the memory including data of a plurality of dialysis input parameters, a plurality of dialysis dwell times, and a plurality of therapy outcomes corresponding to the input parameters and dwell times, wherein a user instructs the microcontroller to select or calculate a dwell time for optimizing at least one dialysis outcome for a patient; and a patient transfer device connected to a patient access device, the patient transfer device including electronics in communication with the microcontroller.
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Specification