Multiplexed pathlength resolved noninvasive analyzer apparatus and method of use thereof
First Claim
1. An apparatus for noninvasive estimation of an analyte concentration of a human subject, comprising:
- a near-infrared noninvasive analyzer, comprising;
a near-infrared source;
a photon transport system configured to transport photons from said near-infrared source to an illumination zone;
a two-dimensional planar transmittance filter array comprising;
a first filter comprising a first fifty percent cut-on transmittance inflection point at a first wavelength in a range of 1200 to 2500 nanometers;
a second filter comprising a second fifty-percent cut-on transmittance inflection at a second wavelength, said second wavelength at least one hundred nanometers shorter than said first wavelength,said first filter positioned closer to the illumination zone than said second filter; and
a detector, said detector configured to detect a sub-set of the photons after the photons undergo diffuse reflection and arrive at a detection zone, both the illumination zone and the detection zone in proximate contact with the subject during use,said two-dimensional planar transmittance filter orientated substantially parallel to a line from the illumination zone to the detection zone.
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Accused Products
Abstract
A noninvasive analyzer apparatus and method of use thereof is described using one or a plurality of sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.
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Citations
19 Claims
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1. An apparatus for noninvasive estimation of an analyte concentration of a human subject, comprising:
a near-infrared noninvasive analyzer, comprising; a near-infrared source; a photon transport system configured to transport photons from said near-infrared source to an illumination zone; a two-dimensional planar transmittance filter array comprising; a first filter comprising a first fifty percent cut-on transmittance inflection point at a first wavelength in a range of 1200 to 2500 nanometers; a second filter comprising a second fifty-percent cut-on transmittance inflection at a second wavelength, said second wavelength at least one hundred nanometers shorter than said first wavelength, said first filter positioned closer to the illumination zone than said second filter; and a detector, said detector configured to detect a sub-set of the photons after the photons undergo diffuse reflection and arrive at a detection zone, both the illumination zone and the detection zone in proximate contact with the subject during use, said two-dimensional planar transmittance filter orientated substantially parallel to a line from the illumination zone to the detection zone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for noninvasive estimation of an analyte concentration of a human subject, comprising, comprising the steps of:
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providing a near-infrared noninvasive analyzer, comprising; a near-infrared source; a photon transport system; and a two-dimensional planar transmittance filter array comprising; a first filter comprising a first fifty percent cut-on transmittance inflection point at a first wavelength in a range of 1200 to 2500 nanometers; a second filter comprising a second fifty-percent cut-on transmittance inflection at a second wavelength, said second wavelength at least one hundred nanometers shorter than said first wavelength, said first filter positioned closer to the illumination zone than said second filter; and transporting the photons from said near-infrared source through an illumination zone; passing the photons through said two-dimensional planar transmittance filter array; and detecting a sub-set of the photons, with a detector, after the photons undergo diffuse reflection and arrive at a detection zone, both the illumination zone and the detection zone proximately contacting the subject, said two-dimensional planar transmittance filter orientated substantially parallel to a line from the illumination zone to the detection zone. - View Dependent Claims (16, 17, 18, 19)
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Specification