Peripheral nerve interface devices for treatment and prevention of neuromas
First Claim
1. An implantable nerve interface cap device to treat, minimize, or prevent neuroma formation in a nerve of a subject, the device comprising:
- a housing comprising a scaffold material, the housing defining an enclosed cylindrical capped structure having a single opening capable of receiving a nerve ending therein; and
an interior region within the housing for receiving an autograft of muscle tissue or dermis tissue from the subject, wherein the interior region facilitates contact of the autograft with a portion of the nerve ending after implantation, so that the nerve ending grows within and innervates the autograft in the interior region of the housing to treat, minimize, or prevent neuroma formation.
3 Assignments
0 Petitions
Accused Products
Abstract
The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and/or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.
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Citations
18 Claims
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1. An implantable nerve interface cap device to treat, minimize, or prevent neuroma formation in a nerve of a subject, the device comprising:
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a housing comprising a scaffold material, the housing defining an enclosed cylindrical capped structure having a single opening capable of receiving a nerve ending therein; and an interior region within the housing for receiving an autograft of muscle tissue or dermis tissue from the subject, wherein the interior region facilitates contact of the autograft with a portion of the nerve ending after implantation, so that the nerve ending grows within and innervates the autograft in the interior region of the housing to treat, minimize, or prevent neuroma formation. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An implantable nerve interface cap device to treat, minimize, or prevent neuroma formation in a nerve of a subject, the device comprising:
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a housing formed of a scaffold material selected from a group consisting of;
a decellularized biotic material, a biological scaffold material, a cellularized biotic or abiotic material, and combinations thereof, wherein the housing defines an enclosed cylindrical capped structure having a single opening capable of receiving a portion of a nerve ending therein;an interior region within the housing for receiving an autograft of muscle tissue or dermis tissue from the subject, wherein the interior region facilitates contact of the autograft with the portion of the nerve ending after implantation, so that the nerve ending grows within and innervates the autograft in the interior region of the housing; and one or more electrodes disposed within at least a portion of the housing in electrical communication with the nerve ending, muscle tissue or dermis tissue, or both the nerve ending and muscle tissue or dermis tissue, wherein the one or more electrodes are used to apply electrical stimulation for pain modulation and/or desensitizing of the nerve ending so that the implantable nerve interface cap device treats, minimizes, or prevents neuroma formation. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A method for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve ending, the method comprising:
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disposing an autograft having a predetermined size comprising muscle tissue or dermis tissue removed from the subject within a housing of an implantable nerve interface cap device, wherein the housing defines an enclosed cylindrical capped structure having a single opening and comprises a scaffold material; and securing a portion of the nerve ending within the housing, wherein the nerve ending contacts the autograft after implanting the nerve interface cap device, so that the nerve ending grows within and innervates the autograft, thus treating, minimizing, or preventing neuroma formation in the nerve ending. - View Dependent Claims (16, 17)
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18. An implantable nerve interface cap device to treat, minimize, or prevent neuroma formation in a nerve of a subject, the device comprising:
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a housing comprising a scaffold material, the housing defining an enclosed cylindrical capped structure having a single opening capable of receiving a nerve ending therein; and an interior region within the housing having an autograft of muscle tissue or dermis tissue from the subject, wherein the interior region facilitates contact of the autograft with a portion of the nerve ending after implantation, so that the nerve ending grows within and innervates the autograft in the interior region of the housing to treat, minimize, or prevent neuroma formation.
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Specification