System and apparatus for reactions

• US 9,352,312 B2
• Filed: 09/23/2011
• Issued: 05/31/2016
• Est. Priority Date: 09/23/2011
• Status: Active Grant

• Current Assignee: Abbott Diagnostics Scarborough, Inc. (Abbott Laboratories Incorporated)
• Original Assignee: Alere Switzerland GmbH (Abbott Laboratories Incorporated)
• Inventors: Grover, Simon Roderick, Wilkins, Paul Graham, Rollings, Nick David, Mayne, Peter Laurence, Chan, Wai Ting, Scott, Natalie Frances, Flick, Olivier Fernand, Innes, Henry Charles, Beedham, Martyn Gray Darnbrough, Long, Nicholas David, Hammond, Richard John
• Primary Examiner(s): HIXSON, CHRISTOPHER
• Application Number:
  US13/242,999
• Publication Number:
  US 20130078736A1
• Time in Patent Office: 1,712 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2200/16 Reagents, handling or storing thereof
• CPC Class Codes: B01L 2300/025 Displaying results or values with integrated means
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Claims

1. A system comprising:

a liquid transfer device comprising a housing having a pipette tip and a plunger assembly;

a fluid reservoir; and

a reaction chamber,

wherein the housing of the liquid transfer device comprises an asymmetrical cross-section that is compatible with a cross-section of a housing of the fluid reservoir and, when mated with the fluid reservoir, the liquid transfer device sealably engages with the fluid reservoir;

wherein the asymmetrical cross-section of the housing of the liquid transfer device is compatible with a cross-section of a housing of the reaction chamber and, when mated with the reaction chamber, the liquid transfer device lockably engages with the reaction chamber; and

wherein the reaction chamber has an asymmetrical cross-section that is compatible with the cross-section of the housing of the fluid reservoir and, when mated with the fluid reservoir, the reaction chamber lockably engages with the fluid reservoir.

2. The system of claim 1, wherein the housing of the liquid transfer device comprises a gasket configured to sealably engage with the reaction chamber.

3. The system of claim 1, wherein the reaction chamber comprises a gasket configured to sealably engage with the liquid transfer device.

4. The system of claim 1, wherein the liquid transfer device is configured to lockably engage with the reaction chamber without dispensing.

5. The system of claim 1, wherein the liquid transfer device is configured to lockably engage with the reaction chamber after dispensing.

6. The system of claim 1, wherein the reaction chamber comprises one or more components of a biological reaction.

7. The system of claim 1, wherein the reaction chamber locks into the fluid reservoir when mated to form an irreversible seal.

8. The system of claim 1,

wherein, when the liquid transfer device is mated with the fluid reservoir, the plunger assembly remains stationary relative to the fluid reservoir and the housing of the liquid transfer device moves relative to the plunger assembly.

9. The system of claim 8, wherein movement of the housing of the liquid transfer device relative to the plunger assembly results in creation of a vacuum within the pipette tip.

10. The system of claim 8, wherein the housing of the liquid transfer device is configured to move relative to the plunger assembly when the housing is advanced toward the fluid reservoir.

11. The system of claim 9, wherein the plunger assembly is configured to lock in a position resulting in creation of the vacuum.

12. The system of claim 9, wherein the device is configured to provide an auditory indication, a visual indication, or both when the plunger assembly is in a position resulting in the creation of the vacuum.

13. The system of claim 8, wherein the reaction chamber is configured to unlock the plunger assembly when the liquid transfer device and the reaction chamber are interfaced.

14. The system of claim 1, wherein the housing of the fluid reservoir comprises an outer wall and an inner wall, wherein the inner wall is spaced apart from and positioned within the outer wall.

15. The system of claim 14, wherein the liquid transfer device and the fluid reservoir sealably engage when mated with:

the plunger assembly engaged with the inner wall of the fluid reservoir, and

the housing of the liquid transfer device positioned between the inner wall and the outer wall of the fluid reservoir.

16. The system of claim 1, wherein the liquid transfer device locks into the reaction chamber.

17. The system of claim 16, wherein the liquid transfer device defines openings and the reaction chamber comprises protrusions, and the liquid transfer device locks into the reaction chamber when the protrusions are seated in the openings.

18. The system of claim 16, wherein the reaction chamber locks into the fluid reservoir.

19. The system of claim 18, wherein the fluid reservoir defines openings, the reaction chamber comprises protrusions, and the fluid reservoir locks into the reaction chamber when the protrusions are seated in the openings.

20. The system of claim 18, wherein the system contains a biological material, and the biological material is sealed within the system.

21. The system of claim 1, wherein:

the pipette tip is a first pipette tip, and

the plunger assembly further comprises a second pipette tip proximate the first pipette tip.