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Compositions and their uses directed to huntingtin

  • US 9,353,372 B2
  • Filed: 01/05/2015
  • Issued: 05/31/2016
  • Est. Priority Date: 01/26/2006
  • Status: Active Grant
First Claim
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1. An antisense oligonucleotide 12 to 35 nucleotides in length comprising at least 12 consecutive nucleotides having at least 90% complementarity to nucleotides 5801-5820 of SEQ ID NO:

  • 4, wherein the antisense oligonucleotide comprises at least one modified internucleoside linkage and/or at least one modified sugar moiety.

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