Detecting mass on a MEMS biooscillating resonator array

• US 9,354,202 B2
• Filed: 09/21/2012
• Issued: 05/31/2016
• Est. Priority Date: 09/21/2011
• Status: Active Grant

• Current Assignee: David Lawrence Medin, James Michael Moniz
• Original Assignee: David Lawrence Medin, James Michael Moniz
• Inventors: Medin, David Lawrence, Moniz, James Michael
• Primary Examiner(s): Kwok, Helen
• Application Number:
  US13/624,694
• Publication Number:
  US 20130068025A1
• Time in Patent Office: 1,348 Days
• Field of Search: 735/79, 735/80, 736/49, 736/57, 73/32.A, 73/240.6, 73/240.3, 73/233, 73/542.4, 73/542.6, 73/544.1, 73/617.5
• US Class Current: 1/1
• CPC Class Codes: G01N 2291/012 Phase angle
• CPC Class Codes: G01N 2291/02466 Biological material, e.g. blood
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves

Abstract

A system configured to determine the mass of an object. The system generates a first output signal by transmitting an excitation signal through an oscillating resonator array. The oscillating resonator array includes a first oscillating resonator, a second oscillating resonator; and an electronic component coupled between the first oscillating resonator and the second oscillating resonator. A user adds an object to a surface of the oscillating resonator array. After adding the object, the system generates a second output signal by transmitting the excitation signal through the oscillating resonator array and determines a phase difference between the first output signal and the second output signal.

Claims

1. A system for determining a mass of an object, the system comprising:

a waveform generator configured to generate an excitation signal;

a comparator bias voltage circuit configured to generate an analog reference signal and sweep the analog reference signal through a range of amplitudes;

a comparator clock;

an oscillating resonator array having the object disposed thereon, the oscillating resonator array being be coated with an attractor substance to preferentially target particular molecules of the object, being coupled to the waveform generator and being configured to receive the excitation signal and generate an output signal;

a comparator coupled to the oscillating resonator array and to the comparator bias voltage circuit; and

a latch circuit coupled to an output of the comparator and to the comparator clock, the latch circuit being configured to capture a moment when the output of the comparator toggles because the analog reference signal becomes larger or smaller than the output signal of the oscillating resonator array and to generate a digital signal.

2. The system of claim 1, further comprising an amplifying component coupled to the oscillating resonator array and to the comparator.

3. The system of claim 1, further comprising a memory to store the digital signal.

4. The system of claim 1, further comprising a processor coupled to the latch circuit, the processor being configured to determine an identity and a concentration of the object based on the digital signal.

5. The system of claim 1, wherein the oscillating resonator array comprises a first oscillating resonator and a second oscillating resonator arranged in one of a series configuration, a parallel configuration and a mixed configuration.

6. The system of claim 1, wherein the oscillating resonator array comprises one or more of:

an active component, a passive component, a third resonator, an impedance altering component and an amplifying component.

7. The system of claim 1, wherein the oscillating resonator array comprises one of an electrostatic resonator, a force piezoelectric resonator, a mechanical resonator, an electrical resonator and a piezoelectric resonator.

8. The system of claim 1, wherein the oscillating resonator array exhibits resonance for a narrow range of frequencies.

9. The system of claim 1, wherein the excitation signal comprises one of an electrostatic field, a charge, a magnetic field, an electromagnetic field and a mechanical impulse.

10. The system of claim 1, wherein the object is a nucleic acid.

11. The system of claim 10, wherein the nucleic acid is one of a deoxyribonucleic acid sample, a ribonucleic acid sample, a peptide nucleic acid sample, an antigen sample and an antibody sample.

12. The system of claim 1, wherein the object is a substance not specifically bound to the surface of the oscillating resonator array.

13. The system of claim 1, wherein the object is a substance specifically bound to the surface of the oscillating resonator array.

14. The system of claim 1, wherein the latch circuit is configured to capture the moment before and after the object is added to the oscillating resonator array.

15. The system of claim 1, further comprising one or more processors configured to determine an identity of the object from the digital signal.

16. The system of claim 15, wherein the one or more processors are configured to determine a concentration of a subset of the object from the digital signal.

17. The system of claim 1, wherein the excitation signal is a periodic signal.