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Substantially surfactant-free, submicron dispersions of hydrophobic agents containing high levels of water miscible solvent

  • US 9,357,770 B2
  • Filed: 03/14/2014
  • Issued: 06/07/2016
  • Est. Priority Date: 03/15/2013
  • Status: Active Grant
First Claim
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1. A composition for application to skin, hair or external mucosa comprising:

  • an aqueous-solvent fluid and submicron particles of hydrophobic agent(s) of average particle size from 100 nm to 999 nm dispersed and suspended in the aqueous-solvent fluid, wherein the submicron particles are 90% wt. or more non-polar, wherein 85% or more of the submicron particles have a size within 300 nm of the average particle size;

    wherein the aqueous-solvent fluid comprises30% to 95% wt. of one or more water miscible solvent(s),4.99% to 70% wt. water, and0.01% to 10% wt. of one or more rheological modifying agent(s);

    wherein 70% wt. or more of the one or more water miscible solvents, and 30% wt. or more of the aqueous-solvent fluid, is one or more mono- or di-hydroxy compounds selected from the group consisting of C2 or C3 alcohols, propylene glycol, butylene glycol or pentylene glycol;

    wherein the hydrophobic agent(s) comprise 0.01 to 70% wt. of the skin, hair or mucosal composition;

    wherein the composition is substantially surfactant-free, wherein the amount of surfactant, if present, is not sufficient to materially lower the surface tension of the aqueous-solvent fluid; and

    wherein the dispersed submicron particles are stable.

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