Implantable biosensor and methods of use thereof
First Claim
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1. A sensor for measuring an analyte, the sensor comprising:
- an oxygen transport region comprising at least one reversible oxygen binding protein;
an analyte reaction region, the analyte reaction region comprising;
an oxygen-permeable surface in communication with the oxygen transport region;
an analyte-permeable surface configured to allow a target analyte to pass through, the analyte-permeable surface located generally orthogonal to the oxygen-permeable surface; and
an analyte reaction chamber at least partially surrounded by the oxygen-permeable surface and the analyte-permeable surface, the reaction chamber configured to retain a target analyte oxidase enzyme;
wherein the oxygen-permeable surface, the analyte-permeable surface, and the analyte reaction chamber are configured to form an oxygen gradient in the analyte reaction region; and
a sensing region comprising at least one detector, wherein the detector is configured to spatially sample the oxygen gradient within the analyte reaction region.
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Abstract
Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
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Citations
15 Claims
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1. A sensor for measuring an analyte, the sensor comprising:
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an oxygen transport region comprising at least one reversible oxygen binding protein; an analyte reaction region, the analyte reaction region comprising; an oxygen-permeable surface in communication with the oxygen transport region; an analyte-permeable surface configured to allow a target analyte to pass through, the analyte-permeable surface located generally orthogonal to the oxygen-permeable surface; and an analyte reaction chamber at least partially surrounded by the oxygen-permeable surface and the analyte-permeable surface, the reaction chamber configured to retain a target analyte oxidase enzyme; wherein the oxygen-permeable surface, the analyte-permeable surface, and the analyte reaction chamber are configured to form an oxygen gradient in the analyte reaction region; and a sensing region comprising at least one detector, wherein the detector is configured to spatially sample the oxygen gradient within the analyte reaction region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification