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System and method for guidance of anesthesia, analgesia and amnesia

  • US 9,357,965 B2
  • Filed: 01/07/2013
  • Issued: 06/07/2016
  • Est. Priority Date: 10/23/2002
  • Status: Expired due to Term
First Claim
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1. A method of determining a desired anesthesia dosage for a patient via a perturbation analysis, comprising:

  • administering to the patient a first interventional agent at a first rate selected to achieve a first predetermined plane of anesthesia;

    analyzing brain waves of the patient to formulate a first set of data corresponding to a self-norm during administration of the first interventional agent;

    computing from the first set of data a first transfer function corresponding to patient biochemical reactions to the first interventional agent;

    altering the rate of administration of the first interventional agent to the patient by a selected amount after achievement of the first plane of anesthesia for a first time required for the patient to deviate from the first plane of anesthesia by a predetermined degree;

    determining an altered amount of the first interventional agent required to cause the predetermined deviation from the first plane of anesthesia as a difference between an amount of the first interventional agent that would have been delivered to the patient during the first time at the first rate and an amount delivered to the patient during the first time at the altered rate; and

    administering to the patient one of the altered amount of the first interventional agent and a portion of the altered amount of the first interventional agent.

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