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Systems and methods for opening of a tissue barrier

  • US 9,358,023 B2
  • Filed: 03/21/2012
  • Issued: 06/07/2016
  • Est. Priority Date: 03/19/2008
  • Status: Active Grant
First Claim
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1. A method for opening a tissue to a target value using microbubbles, comprising;

  • targeting a region of said tissue to open;

    determining at least one acoustic parameter corresponding to said target value, wherein said at least one acoustic parameter is selected to control a magnitude and a type of one or more acoustic cavitation events to open said tissue to said target value, and wherein said target value corresponds to a treatment and/or imaging value to allow passage of certain molecules and/or agents; and

    applying an ultrasound beam at said at least one acoustic parameter to said targeted region such that said tissue is opened with said microbubbles to said target value.

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