Drug delivery device with piston proximity sensing

• US 9,358,336 B2
• Filed: 03/26/2013
• Issued: 06/07/2016
• Est. Priority Date: 03/27/2012
• Status: Expired due to Fees

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Munk, Jens A., Andersen, Carsten S., Larsen, Bjorn G., Holm, Per E.
• Primary Examiner(s): HAYMAN, IMANI N
• Application Number:
  US14/387,558
• Publication Number:
  US 20150080790A1
• Time in Patent Office: 1,169 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54

Abstract

Drug delivery device with electronically controlled and axially displaceable piston drive member (10) adapted to engage a loaded cartridge piston. The piston drive member is moveable between a proximal loading position in which a cartridge can be received and a distal loaded position in engagement with the piston. A proximity sensor (11,12) provides a varying output indicative of a varying distance between the piston drive member and the piston. A controller (30) coupled to the proximity sensor is configured to control movement of the piston drive member from the loading position to the loaded position and stop movement when the controller based on input from the proximity sensor system determines that the loaded position has just been reached. By this arrangement it is prevented that a drug-filled cartridge is pressurized during the loading and initializing procedure.

Claims

1. A drug delivery device comprising:

a compartment adapted to receive a cartridge in a loaded position, the cartridge comprising a body portion, a distal outlet portion and an axially displaceable piston with a proximal portion,

an electronically controlled expelling assembly comprising an axially displaceable piston drive member adapted to engage the proximal piston portion of the cartridge, the piston drive member being moveable between a proximal loading position and a distal loaded position in engagement with the proximal piston portion,

a proximity sensor system adapted to provide a varying output indicative of a varying distance between the piston drive member and the proximal piston portion,

a first light source providing a light directed at least in part against the proximal piston portion of the cartridge,

a light sensor coupled to the piston drive member and adapted to measure light from the first light source reflected from the proximal piston portion of the cartridge,

whereby the first light source and the light sensor provide at least in part a proximity sensor system adapted to provide an output indicative of the distance between the proximal piston portion and the piston drive member

a controller coupled to the proximity sensor system and the expelling assembly and configured to control the expelling assembly to move the piston drive member from the loading position to the loaded position and stop movement when the controller based on input from the proximity sensor system determines that the loaded position has just been reached,

the controller further configured to;

determine a first condition in which the piston drive member and the proximal piston portion of the cartridge are at a loading distance from each other corresponding to the loading position of the piston drive member and in which a low level of reflected light is directed to and measured by the light sensor,

determine a second condition in which the piston drive member and the proximal piston portion of the cartridge are at an intermediate distance from each other corresponding to an intermediate position of the piston drive member and in which an intermediate level of reflected light is directed to and measured by the light sensor,

determine a third condition in which the piston drive member and the proximal piston portion of the cartridge are in engagement with each other corresponding to the loaded position of the piston drive member and in which a low level of reflected light is directed to and measured by the light sensor, and

control the expelling assembly to move the piston drive member from the loading position, through the intermediate position to the loaded position, and stop movement when the loaded position has been reached.

2. The drug delivery device as in claim 1, wherein at least a part of the proximity sensor system is coupled to and moves with the piston drive member.

3. The drug delivery device as in claim 1, wherein the first light source is coupled to and moves with the piston drive member.

4. The drug delivery device as in claim 1, further comprising:

a light barrier structure associated with the light sensor and adapted to block or reduce light from reaching the light sensor when the piston drive member has been moved into engagement with the proximal piston portion.

5. The drug delivery device as in claim 1, wherein the controller is configured to control the expelling assembly to move the piston drive member at a varying speed corresponding to the varying output provided by the proximity sensor system, this allowing a given speed of the piston drive member to be reduced as it approaches the proximal piston portion.

6. The drug delivery device as in claim 1, further comprising:

a second light source arranged stationary relative to the piston drive member and providing backlight,

wherein the light sensor is adapted to also measure backlight from the second light source, and

wherein the controller is configured to;

determine a first condition in which the piston drive member and the proximal piston portion of the cartridge are at a loading distance from each other corresponding to the loading position of the piston drive member and in which a high level of backlight and a low level of reflected light are directed to and measured by the light sensor,

determine a second condition in which the piston drive member and the proximal piston portion of the cartridge are at an intermediate distance from each other corresponding to an intermediate position of the piston drive member and in which an intermediate level of backlight and an intermediate level of reflected light are directed to and measured by the light sensor,

determine a third condition in which the piston drive member and the proximal piston portion of the cartridge are in engagement with each other corresponding to the loaded position of the piston drive member and in which a low level of backlight and a low level of reflected light are directed to and measured by the light sensor, and

control the expelling assembly to move the piston drive member from the loading position, through the intermediate position to the loaded position, and stop movement when the loaded position has been reached.

7. The drug delivery device as in claim 1, wherein the piston drive member is moved at a first speed between the loading and intermediate position, and is moved at a second lower speed between the intermediate and the loaded position.

8. The drug delivery device as in claim 6, wherein the first light source emits a first type of light and the second light source emits a second type of light.

9. The drug delivery device as in claim 1, wherein the controller, after the loaded position has been reached, is adapted to be set to axially move the piston drive element a given distance to thereby expel an amount of drug from the cartridge.

10. The drug delivery device as in claim 1, in combination with:

a drug-filled cartridge comprising an axially displaceable piston having a proximal portion, the proximal portion comprising a surface adapted to reflect light as well as an engagement portion adapted to engage the piston drive member.

11. A drug delivery device comprising:

a compartment adapted to receive a cartridge in a loaded position cartridge, the cartridge comprising a body portion, a distal outlet portion and an axially displaceable piston with a proximal portion,

an electronically controlled expelling assembly comprising an axially displaceable piston drive member adapted to engage the proximal piston portion of the cartridge, the piston drive member being moveable between a proximal loading position and a distal loaded position in engagement with the proximal piston portion,

a proximity sensor system adapted to provide a varying output indicative of a varying distance between the piston drive member and the proximal piston portion,

a first light source providing a light directed at least in part against the proximal piston portion of the cartridge,

a second light source arranged stationary relative to the piston drive member and providing backlight,

a light sensor coupled to the piston drive member and adapted to measure light from the first light source reflected from the proximal piston portion of the cartridge,

whereby the first light source and the light sensor provide at least in part a proximity sensor system adapted to provide an output indicative of the distance between the proximal piston portion and the piston drive member, and

wherein the light sensor is adapted to also measure backlight from the second light source,

a controller coupled to the proximity sensor system and the expelling assembly and configured to control the expelling assembly to move the piston drive member from the loading position to the loaded position and stop movement when the controller based on input from the proximity sensor system determines that the loaded position has just been reached,

wherein the controller is configured to;

determine a first condition in which the piston drive member and the proximal piston portion of the cartridge are at a loading distance from each other corresponding to the loading position of the piston drive member and in which a high level of backlight and a low level of reflected light are directed to and measured by the light sensor,

determine a second condition in which the piston drive member and the proximal piston portion of the cartridge are at an intermediate distance from each other corresponding to an intermediate position of the piston drive member and in which an intermediate level of backlight and an intermediate level of reflected light are directed to and measured by the light sensor,

determine a third condition in which the piston drive member and the proximal piston portion of the cartridge are in engagement with each other corresponding to the loaded position of the piston drive member and in which a low level of backlight and a low level of reflected light are directed to and measured by the light sensor, and

control the expelling assembly to move the piston drive member from the loading position, through the intermediate position to the loaded position, and stop movement when the loaded position has been reached.