Method and assembly for a drug delivery device

• US 9,358,340 B2
• Filed: 09/29/2010
• Issued: 06/07/2016
• Est. Priority Date: 09/30/2009
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Jones, Christopher, Veasey, Robert, Kouyoumjian, Garen, MacDonald, Catherine Anne, Jugl, Michael, Sendatzki, Gunther
• Primary Examiner(s): Bosworth, Kami A
• Assistant Examiner(s): Engel, Matthew A
• Application Number:
  US13/496,337
• Publication Number:
  US 20120289906A1
• Time in Patent Office: 2,078 Days
• Field of Search: 604/154, 604/191, 604/110, 604/195, 604/132, 604/187, 604/228
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2477 comprising means to reduce play of ampoule within ampoule holder, e.g. springs
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2205/6045 having complementary physical shapes for indexing or registration purposes
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31555 by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub
• CPC Class Codes: A61M 5/344 using additional parts, e.g. clamping rings or collets
• CPC Class Codes: A61M 5/347 rotatable, e.g. bayonet or screw A61M5/344 takes precedence
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

A method for securing a cartridge (4) in a cartridge holder (3) is provided, the method comprising the steps of

• • inserting the cartridge (4) into the cartridge holder (3), the cartridge holder (3) having a proximal end and a distal end,
  • axially displacing the cartridge (4) in a proximal direction with respect to the cartridge holder (3) from a distal initial position to a proximal end position and
  • securing the cartridge (4) in the end position against displacement in the distal direction with respect to the cartridge holder (3). An assembly for a drug delivery device (1) is provided comprising a cartridge (4), an adjusting member (12, 25, 28, 34) and a cartridge holder (3). The cartridge holder (3) has a distal end and a proximal end. The adjusting member (12, 25, 28, 34) is secured to the cartridge holder (3). The adjusting member (12, 25, 28, 34) holds a distal portion of the cartridge (4) at a distance with respect to a distal portion of the cartridge holder (3).

Claims

1. A method for securing a cartridge in a cartridge holder of a drug delivery device, wherein the drug delivery device is configured to dispense at least one dose of a drug, the method comprising the following steps:

providing the cartridge comprising a piston, wherein a distal portion of the cartridge comprises an outwardly directed shoulder portion,

inserting the cartridge into the cartridge holder, the cartridge holder comprising a proximal end and a distal end, wherein a distal portion of the cartridge holder comprises an inwardly directed flange portion,

the shoulder portion of the cartridge being suitable dimension to abut the flange portion of the cartridge holder,

prior to dose dispense, utilizing an adjusting member to axially displace the cartridge in a proximal direction with respect to the cartridge holder from a distal initial position to a proximal end position, so as to reduce a gap between a piston rod and the piston of the cartridge,

utilizing the adjusting member to secure the cartridge in the proximal end position against displacement in a distal direction with respect to the cartridge holder, and

preventing an abutment of the shoulder portion of the cartridge and the flange portion of the cartridge holder,

wherein the adjusting member is used for securing the cartridge in the cartridge holder and wherein securing the cartridge in the cartridge holder comprises securing the adjusting member against displacement with respect to the cartridge holder in the distal direction when the cartridge is in the proximal end position, and

wherein the adjusting member extends from an inside of the cartridge holder to an outside of the cartridge holder, wherein an outer surface of the adjusting member accessible from the outside of the cartridge holder is provided for attaching a needle unit to the adjusting member.

2. The method of claim 1, wherein the adjusting member is displaced in the proximal direction with respect to the cartridge holder for axially displacing the cartridge.

3. The method according to claim 2, wherein the adjusting member is reversibly fixed to the cartridge holder.

4. The method according to claim 1, wherein the outer surface of the adjusting member is threaded.

5. The method according to claim 1, wherein the adjusting member comprises an outer thread which engages an inner thread of the cartridge holder, thereby securing the adjusting member to the cartridge holder.

6. A method for assembling a drug delivery device, comprising the steps of:

providing a cartridge containing a drug, a piston being retained within the cartridge, providing a cartridge holder,

providing a housing, a piston rod being retained in the housing, the piston rod being operable to displace the piston with respect to the cartridge,

securing the cartridge holder to the housing, such that the piston is arranged at a distance from the piston rod,

securing the cartridge in the cartridge holder according to the method of claim 1, wherein, when the cartridge is axially displaced in the proximal direction with respect to the cartridge holder away from an initial position, the piston is displaced towards the piston rod.

7. The method according to claim 6, comprising the step of, during an axial displacement of the cartridge with respect to the cartridge holder, detecting whether the piston abuts the piston rod and, if so, stopping the axial displacement of the cartridge with respect to the cartridge holder in a proximal end position and securing the cartridge against displacement in a distal direction with respect to the cartridge holder.

8. The method according to claim 6, wherein the cartridge has an outlet at its distal end, a septum sealing the outlet, and wherein the piston seals the cartridge proximally.