Methods and systems for presenting a combination treatment

• US 9,358,361 B2
• Filed: 02/14/2014
• Issued: 06/07/2016
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Harvest Bio LLC
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Sweeney, Elizabeth A., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): NGUYEN, HIEP VAN
• Application Number:
  US14/181,540
• Publication Number:
  US 20140275739A1
• Time in Patent Office: 844 Days
• Field of Search: 705/2
• US Class Current: 1/1
• CPC Class Codes: A61M 2021/005 images, e.g. video
• CPC Class Codes: A61M 2021/0077 with application of chemical or pharmacological stimulus
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual.

Claims

1. A system comprising:

at least one dispenser operable to release one or more unit dosages of at least one anti-addiction agent;

at least one anti-addiction agent disposed within the at least one dispenser for release in accordance with at least one administration schedule; and

one or more media associated with the at least one dispenser, the one or more non-transitory media bearing one or more codes for accessing online digital content for implementation of at least one digital therapy application, the one or more codes associated with the at least one dispenser being readable by

at least one smartphone device including at least;

at least one user interface,

at least one wireless transceiver; and

at least one processor component, to perform special purpose operations including at least;

configuring the at least one processor component to output at least one indication to administer the at least one anti-addiction agent of the at least one dispenser in accordance with the at least one administration schedule,

configuring the at least one processor component to implement the at least one digital therapy application at one or more times that is coordinated with at least one time of administration of the at least one anti-addiction agent based on at least one pharmacokinetic profile of the at least one anti-addiction agent,

configuring the at least one processor component to monitor at least one effect on an individual at one or more specified times relative to implementation of the at least one digital therapy application and administration of the at least one anti-addiction agent, and

configuring the at least one processor component to transmit wirelessly at least one aggregation of one or more health results for access by at least one health provider.

2. A computer process for controlling a system that includes at least one dispenser including at least one anti-addiction agent for release in accordance with at least one administration schedule and one or more media bearing one or more codes for accessing online digital content for implementation of at least one digital therapy application, and at least one smartphone device including at least one user interface, at least one wireless transceiver, and at least one processor component, the computer process including special purpose operations comprising:

outputting by the at least one processor component at least one indication to administer the at least one anti-addiction agent of the at least one dispenser in accordance with the at least one administration schedule;

implementing by the at least one processor component the at least one digital therapy application at one or more times that is coordinated with at least one time of administration of the at least one anti-addiction agent based on at least one window of effectiveness of the at least one anti-addiction agent;

monitoring by the at least one processor component at least one effect on an individual at one or more specified times relative to implementation of the at least one digital therapy application and administration of the at least one anti-addiction agent; and

transmitting wirelessly by the at least one wireless transceiver at least one aggregation of one or more health results for access by at least one health provider.

3. A computer process for controlling a system that includes at least one dispenser including at least one pharmaceutical agent for administration, and at least one smartphone device including at least one communication device, at least one processor component, and at least one user interface, the computer process including special purpose operations comprising:

obtaining by the at least one processor component information from the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device;

outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times;

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent; and

detecting one or more specified reactions of an individual based at least partly on at least one test function at least partly in response to implementation of the at least one aspect of the at least one interactive experience.

4. The process of claim 3, further comprising:

reporting at least one monitored effect to at least one medical professional.

5. The process of claim 3, further comprising:

reporting compliance data to at least one medical professional.

6. The process of claim 3, wherein the obtaining by the at least one processor component information from the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device comprises:

obtaining by the at least one processor component one or more digital codes from one or more media associated with the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device.

7. The process of claim 3, wherein the obtaining by the at least one processor component information from the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device comprises:

obtaining by the at least one processor component information from the at least one dispenser for accessing at least one of the following types of interactive experiences for implementation on the at least one smartphone device;

digital therapy, virtual world, computer game, online course, visual stimulus, or auditory stimulus.

8. The process of claim 3, wherein the obtaining by the at least one processor component information from the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device comprises:

obtaining by the at least one processor component information from the at least one nasal, intravenous, physical intervention module, or container dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device.

9. The process of claim 3, wherein the outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times comprises:

outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times to treat at least one mental condition.

10. The process of claim 3, wherein the outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times comprises:

outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one anti-addiction or withdrawal pharmaceutical agent from the at least one dispenser at one or more specified times.

11. The process of claim 3, wherein the outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times comprises:

outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one anti-anxiety pharmaceutical agent from the at least one dispenser at one or more specified times.

12. The process of claim 3, wherein the outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times comprises:

outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times to treat at least one of the following types of conditions;

anxiety, behavior, depression, fear, inattention, mood disturbance, phobia, psychotic disorder, eating disorder, developmental disorder, communication disorder, social disorder, panic disorder, schizophrenia, obsessive compulsive disorder, addiction, or personality disorder.

13. The process of claim 3, wherein the outputting by the at least one processor component one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times comprises:

outputting by the at least one processor component to the at least one user interface one or more instructions to administer at least one dosage of the at least one pharmaceutical agent from the at least one dispenser at one or more specified times.

14. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more times when plasma concentration of the at least one pharmaceutical agent is expected to be below a substantially effective level based on a pharmacokinetic profile of the at least one pharmaceutical agent and an administration schedule of the at least one pharmaceutical agent.

15. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times being based at least partly on a pharmacokinetic profile that is determined based on at least one attribute of an individual to whom the at least one pharmaceutical agent is administered.

16. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to at least one of concentration or bioavailability of the at least one pharmaceutical agent.

17. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more peak levels of effectiveness of the at least one pharmaceutical agent.

18. The process of claim 3, wherein the obtaining by the at least one processor component information from the at least one dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device comprises:

obtaining by the at least one processor component one or more digital codes from at least one packaging unit dispenser for accessing at least one interactive experience for implementation on the at least one smartphone device.

19. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more lowest levels of effectiveness of the at least one pharmaceutical agent.

20. The process of claim 3, wherein the implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more times relative to administration of the at least one pharmaceutical agent, the one or more times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent comprises:

implementing by the at least one processor component at least one aspect of the at least one interactive experience at one or more staggered times relative to administration of the at least one pharmaceutical agent, the one or more staggered times corresponding to one or more levels of effectiveness of the at least one pharmaceutical agent.

21. The process of claim 3, wherein the detecting one or more specified reactions of an individual based at least partly on at least one test function at least partly in response to implementation of the at least one aspect of the at least one interactive experience comprises:

detecting one or more of the following parameters of an individual at least partly in response to implementation of the at least one aspect of the at least one interactive experience;

visual field, eye movement, pupil movement, face pattern, motor skill, iris dilation, iris constriction, input, gaze tracking, skin response, physical activity, body weight, body mass, heart rate, blood oxygen level, blood pressure, physiological activity, brain activity, behavior, compliance, voice, or hearing.

22. The process of claim 3, wherein the detecting one or more specified reactions of an individual based at least partly on at least one test function at least partly in response to implementation of the at least one aspect of the at least one interactive experience comprises:

detecting one or more specified reactions of an individual based at least partly on at least one test function in near real-time or real-time to implementation of the at least one aspect of the at least one interactive experience.

23. A system comprising:

at least one dispenser operable to release one or more unit dosages of at least one pharmaceutical agent and comprising one or more codes, the one or more codes associated with the at least one dispenser being readable by at least one smartphone device to perform operations including at least;

outputting at least one indication to administer the at least one pharmaceutical agent of the at least one dispenser in accordance with at least one administration schedule,

implementing the at least one digital therapy application at one or more times that is coordinated with at least one time of administration of the at least one pharmaceutical agent based on at least one level of effectiveness of the at least one pharmaceutical agent,

monitoring at least one effect on an individual at one or more specified times relative to implementation of the at least one digital therapy application and administration of the at least one pharmaceutical agent, and

transmitting wirelessly one or more monitoring results for access by at least one health provider.

24. The system of claim 23, wherein the at least one dispenser operable to release one or more unit dosages of at least one pharmaceutical agent comprises:

at least one blister pack containing one or more unit dosages of at least one pharmaceutical agent for release.