Method and system for blocking nerve conduction

• US 9,358,374 B2
• Filed: 04/10/2015
• Issued: 06/07/2016
• Est. Priority Date: 12/05/2007
• Status: Active Grant

• Current Assignee: Soovu Labs, Inc.
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Dacey, Ralph G. Jr., Della Rocca, Gregory J., Derdeyn, Colin P., Dowling, Joshua L., Goodall, Eleanor V., Hyde, Roderick A., Ishikawa, Muriel Y., Kare, Jordin T., Leuthardt, Eric C., Myhrvold, Nathan P., Smith, Michael A., Wood, Lowell L. Jr., Wood, Victoria Y. H., Zipfel, Gregory J.
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US14/683,198
• Publication Number:
  US 20150283365A1
• Time in Patent Office: 424 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61F 7/0085 Devices for generating hot or cold treatment fluids
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2205/0244 : Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2210/1003 : Spinal column
• CPC Class Codes: A61M 35/10 : Wearable devices, e.g. garments, glasses or masks
• CPC Class Codes: A61M 37/00 : Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61M 37/0092 : using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 : of the skin patch type
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation
• CPC Class Codes: A61M 5/16827 : controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/0412 : Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
• CPC Class Codes: A61N 1/0428 : Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/30 : Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/303 : Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/306 : Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 : for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/327 : for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61N 1/36103 : Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/36135 : using physiological parameters
• CPC Class Codes: A61N 1/37252 : Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: A61N 2/002 : in combination with another treatment
• CPC Class Codes: A61N 2/006 : for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2007/0026 : Stimulation of nerve tissue
• CPC Class Codes: A61N 7/00 : Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures are disclosed. Neural activity may blocked cyclically by blocking stimuli delivered via various types of blocking stimulus sources. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of blocking stimuli may be controlled in part in response to an input from a user input device.

Claims

1. A neural modulation system comprising:

a blocking stimulus source adapted to produce a blocking stimulus configured to reversibly block conduction in at least a portion of a peripheral neural structure of a subject;

a first signal input structure adapted to receive a user input signal indicative of an instruction from a user regarding operation of the neural modulation system to deliver the blocking stimulus, the user input signal transmitted from a user input device adapted to receive a user input from the user of the neural modulation system;

a second signal input structure adapted to receive an activity signal indicative of an activity state of at least a portion of a body of the subject innervated by the peripheral neural structure from a sensor operatively connected to the signal input structure; and

signal processing circuitry adapted to

receive the user input signal from the first signal input structure;

modify operation of the neural modulation system responsive to receipt of the user input signal;

distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the activity signal received at the second signal input structure; and

generate a blocking stimulus control signal for driving production of the blocking stimulus by the stimulus source, the blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state.

2. The neural modulation system of claim 1, wherein the blocking stimulus source is adapted to be implanted in the body of the subject.

3. The neural modulation system of claim 1, wherein the blocking stimulus source is adapted to be positioned on or substantially adjacent to the body of the subject.

4. The neural modulation system of claim 1, wherein the blocking stimulus source includes at least one of an electrical blocking stimulus source, a magnetic blocking stimulus source, an ultrasonic blocking stimulus source, an optical blocking stimulus source, a thermal blocking stimulus source, and a chemical blocking stimulus source.

5. The neural modulation system of claim 1, wherein the first signal input structure is adapted to receive a signal from at least one of a user controlled intermediate device, a cell phone, a computer, and a remote controller.

6. The neural modulation system of claim 1, wherein at least one of the first signal input structure and the second signal input structure is adapted to receive at least one of an analog signal, a digital signal, an optical signal, an acoustic signal, an electromagnetic signal, an inductively transmitted signal, a wirelessly transmitted signal, and a signal transmitted via a wired connection.

7. The neural modulation system of claim 1, wherein the first signal input structure is adapted to receive at least one of a user input signal indicative of an instruction from the user to override delivery of the blocking stimulus, a user input signal indicative of an instruction from the user to modify a pattern of delivery of the blocking stimulus, and a user input signal indicative of an instruction from the user to modify a definition of at least one of the first activity state and the second activity state.

8. A neural modulation system comprising:

a blocking stimulus source adapted to produce a blocking stimulus configured to reversibly block conduction in at least a portion of a peripheral neural structure of the subject;

a user input device adapted to receive a user input from a user of the neural modulation system, the user input indicative of an instruction from the user regarding operation of the neural modulation system to deliver the blocking stimulus;

a signal input structure adapted to receive a signal indicative of an activity state of at least a portion of a body of the subject innervated by the peripheral neural structure from a sensor operatively connected to the signal input structure;

signal processing circuitry adapted to

receive a signal indicative of the instruction from the user regarding operation of the neural modulation system;

modify operation of the neural modulation system responsive to receipt of the signal indicative of the instruction from the user;

distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and

generate a blocking stimulus control signal for driving production of the blocking stimulus by the stimulus source, the blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state.

9. The neural modulation system of claim 8, wherein the blocking stimulus source includes at least one of an electrical blocking stimulus source, a magnetic blocking stimulus source, an ultrasonic blocking stimulus source, an optical blocking stimulus source, a thermal blocking stimulus source, and a chemical blocking stimulus source.

10. The neural modulation system of claim 8, wherein the signal input structure is adapted to receive the signal indicative of the activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the sensor via at least one of a wireless connection, an optical connection, an acoustic connection, an electromagnetic connection, and a wired connection.

11. The neural modulation system of claim 8, wherein the user input device includes at least one of a voice activated input, a sound activated input, a switch, a knob, a keyboard, a mouse, a touch screen, at least a portion of a cell phone, at least a portion of a remote controller, and at least a portion of a computer.

12. The neural modulation system of claim 8, wherein the user input is indicative of at least one of an instruction from the user to override delivery of the blocking stimulus, an instruction from the user to modify a pattern of delivery of the blocking stimulus, and an instruction from the user to modify a definition of at least one of the first activity state and the second activity state.

13. A method of controlling a neural modulation system comprising:

receiving at a first signal input structure a user input signal indicative of an instruction from a user regarding operation of a neural modulation system to deliver a blocking stimulus configured to reversibly block conduction in at least a portion of a peripheral neural structure of a subject, the user input signal transmitted from a user input device adapted to receive a user input indicative of the instruction from the user;

receiving at a second signal input structure an activity signal indicative of an activity state of at least a portion of a body of the subject innervated by the peripheral neural structure from a sensor operatively connected to the signal input structure;

modifying operation of the neural modulation system responsive to receipt of the user input signal;

distinguishing a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the activity signal received at the second signal input structure; and

generating a blocking stimulus control signal for driving production of the blocking stimulus by a blocking stimulus source, the blocking stimulus configured to reversibly block conduction in at least a portion of a peripheral neural structure of the subject during at least a portion of the first activity state.

14. A method comprising:

receiving at a user input device an instruction from a user regarding operation of a neural modulation system to deliver a blocking stimulus configured to reversibly block conduction in at least a portion of a peripheral neural structure of a subject;

wirelessly transmitting a user input signal indicative of the instruction from the user from the user input device to a neural stimulation system, the neural modulation system including

a blocking stimulus source adapted to produce the blocking stimulus;

a first signal input structure adapted to receive the user input signal indicative of the instruction from the user;

a second signal input structure adapted to receive an activity signal indicative of an activity state of at least a portion of a body of the subject innervated by the peripheral neural structure;

signal processing circuitry adapted to

receive the user input signal from the first signal input structure and modify operation of the neural modulation system responsive to receipt of the user input signal;

distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the second signal input structure; and

generate a blocking stimulus control signal for driving production of the blocking stimulus by the blocking stimulus source, the blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state.

15. A method of modulating an undesired sensation in a subject, comprising:

receiving a signal indicative of a first activity state or a second activity state of at least a portion of the body of a subject;

delivering a blocking stimulus sufficient to produce a reversible conduction block in at least a portion of a peripheral neural structure of the subject, the reversible conduction block sufficient to modulate an undesired sensation resulting from peripheral neural activity in the peripheral neural structure, the blocking stimulus delivered in response to receipt of the signal indicative of the first activity state or the second activity state of a subject, wherein the blocking stimulus is delivered by a blocking stimulus source positioned substantially adjacent a skin surface in the vicinity of the peripheral neural structure; and

repeating delivery of the blocking stimulus in a cyclical application pattern, the cyclical application pattern including;

a blocking period during which the blocking stimulus is applied at least intermittently, the blocking period coinciding at least in part with the first activity state in the subject; and

a release period during which no blocking stimulus is applied, the release period coinciding at least in part with the second activity state in the subject.

16. A neural modulation system, comprising:

a package configured to be secured to a portion of a body of a subject adjacent a skin surface in the vicinity of a peripheral neural structure;

a signal input structure configured to receive a signal indicative of an activity state of the subject;

a blocking stimulus source, the blocking stimulus source adapted to produce a blocking stimulus sufficient to reversibly block conduction in at least a portion of the peripheral neural structure; and

a signal processing portion within the package, the signal processing portion including circuitry configured to;

distinguish a first activity state of the subject from a second activity state of the subject based on the signal received at the signal input structure; and

generate a blocking stimulus control signal for driving production of the blocking stimulus by the blocking stimulus source in a cyclical application pattern in response to at least one of the first activity state and the second activity state.

17. The neural modulation system of claim 16, wherein the signal input structure is configured to receive the signal indicative of the activity state of the subject from a sensor adapted to sense a parameter indicative of an activity state of the subject.

18. The neural modulation system of claim 17, wherein the sensor is associated with the package.

19. The neural modulation system of claim 18, wherein the sensor includes at least one of a pressure sensor, a force sensor, a chemical sensor, a temperature sensor, an electrical sensor, a magnetic sensor, an optical sensor, a motion sensor, an accelerometer, a gyro, a mercury switch, a piezoelectric device, a switch, a physiological sensor, a sensor configured to generate a signal indicative of activity of a heart of the subject, a sensor configured to generate a signal indicative of activity of a peripheral neural system of the subject, a sensor configured to generate a signal indicative of activity of a muscle of the subject, or a sensor configured to generate a signal indicative a body temperature of the subject.

20. The neural modulation system of claim 16, wherein the signal input structure is configured to receive the signal indicative of the activity state of the subject from a user input device, the user input device including at least one of a voice or sound activated input, a switch, a knob, a keyboard, a mouse, a touch screen, a remote controller, a cell phone, or a remote computer operated by the user.

21. An article of manufacture, comprising:

one or more non-transitory, machine-readable, data storage media bearing one or more instructions relating to;

receiving a signal indicative of a first activity state or a second activity state of a subject;

delivering a blocking stimulus sufficient to produce a reversible conduction block in at least a portion of a peripheral neural structure of the subject, the reversible conduction block sufficient to modulate an undesired sensation resulting from peripheral neural activity in the peripheral neural structure, the blocking stimulus delivered in response to receipt of the signal indicative of the first activity state or the second activity state of a subject, wherein the blocking stimulus is delivered by a blocking stimulus source positioned substantially adjacent a skin surface in the vicinity of the peripheral neural structure; and

repeating delivery of the blocking stimulus in a cyclical application pattern, the cyclical application pattern including;

a blocking period during which the blocking stimulus is applied at least intermittently, the blocking period coinciding at least in part with the first activity state in the subject; and

a release period during which no blocking stimulus is applied, the release period coinciding at least in part with the second activity state in the subject.