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Neural modulation devices and methods

  • US 9,358,395 B2
  • Filed: 08/06/2014
  • Issued: 06/07/2016
  • Est. Priority Date: 06/11/2010
  • Status: Expired due to Fees
First Claim
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1. A system for treating a gastrointestinal disorder or a condition associated with excess weight in a subject in need thereof comprising:

  • at least one electrode adapted to be placed at a vagus nerve;

    an implantable neuroregulator configured to apply a therapy cycle to the electrode, wherein each therapy cycle comprises a) a high frequency burst of electrical signal having a first selected frequency of at least 1000 Hz, wherein the high frequency burst of electrical signals comprises one or more pulses that have a pulse width of about 0.01 milliseconds to about 0.09 milliseconds, and a current of about 0.1 to 20 mAmps;

    b)more than one burst having a low frequency, each burst having a second selected low frequency of at least 40 Hz and less than 150 Hz, wherein each of the bursts of low frequency electrical signals comprises one or more pulses that have a pulse width of about 0.05 microseconds to about 0.5 microseconds, a current of about 0.1 to 20 mAmps and a delay period between each burst;

    wherein the high frequency and low frequency are delivered during the same therapy cycle and at least partially downregulate activity on the nerve;

    c) an on period of at least 2 minutes d) an off period, wherein the off period is selected to allow at least partial recovery of nerve activity; and

    e) a total charge of about 5 to 1000 microcoulombs or less per therapy cycle.

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