Compounds for immunoproteasome inhibition
First Claim
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1. A compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof,
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Abstract
One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.
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18 Claims
- 1. A compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof,
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15. A compound which has the structure
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