Single chain trail fusion polypeptides and encoding nucleic acids
First Claim
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1. A single-chain fusion polypeptide comprising:
- (i) a first soluble TNF-related apoptosis-inducing ligand (TRAIL) cytokine domain,(ii) a first peptide linker,(iii) a second soluble TRAIL cytokine domain,(iv) a second peptide linker, and(v) a third soluble TRAIL cytokine domain,wherein each of the soluble TRAIL domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids.
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Abstract
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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Citations
18 Claims
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1. A single-chain fusion polypeptide comprising:
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(i) a first soluble TNF-related apoptosis-inducing ligand (TRAIL) cytokine domain, (ii) a first peptide linker, (iii) a second soluble TRAIL cytokine domain, (iv) a second peptide linker, and (v) a third soluble TRAIL cytokine domain, wherein each of the soluble TRAIL domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification