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Methods and systems for measuring and using the oxidation-reduction potential of a biological sample

  • US 9,360,446 B2
  • Filed: 10/23/2013
  • Issued: 06/07/2016
  • Est. Priority Date: 10/23/2012
  • Status: Expired due to Fees
First Claim
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1. A method for diagnosing, evaluating or monitoring a subject for brain injury, comprising:

  • a. measuring a capacity oxidation-reduction potential (cORP) of the subject, wherein measuring the cORP of the subject comprises;

    passing a current through a fluid sample obtained from the subject; and

    monitoring a voltage across the fluid sample while passing the current through the fluid sample over at least a first period of time;

    determining a quantity of charge passed to the fluid sample during the first period of time to obtain the cORP of the subject;

    b. comparing the measured cORP to a reference value to determine a brain injury status of the subject, wherein the reference value is one of;

    1) a normal reference value, wherein a measured cORP value that is less than the normal reference value indicates a risk of a brain injury; and

    2) a brain injury reference value, wherein a measured cORP value that is greater than the brain injury reference value indicates an absence of a brain injury; and

    c. treating the subject based on the brain injury status of the subject.

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