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Method and apparatus for the assessment of medical images

  • US 9,361,686 B2
  • Filed: 12/14/2012
  • Issued: 06/07/2016
  • Est. Priority Date: 12/15/2011
  • Status: Active Grant
First Claim
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1. A method of determining the degree of uptake of a PET marker in an individual candidate PET scan, the method including the steps of:

  • (a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals;

    (b) computing a series of brain surfaces from the matched templates;

    (c) aligning the individual candidate PET scan with the matched templates;

    (d) aligning the series of brain surfaces with the candidate PET scan, wherein each of the brain surfaces aligned with the candidate PET scan includes a plurality of surface locations;

    (e) selecting M templates for each of the plurality of surface locations based on a similarity measure between the candidate PET scan and a corresponding controlled PET template;

    (f) computing M weights for each of the plurality of surface locations utilizing a corresponding MRI template tissue map;

    (g) utilizing the M weights to combine the M templates for each of the plurality of surface locations to form an average brain surface indicator.

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