Method and apparatus for the assessment of medical images
First Claim
1. A method of determining the degree of uptake of a PET marker in an individual candidate PET scan, the method including the steps of:
- (a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals;
(b) computing a series of brain surfaces from the matched templates;
(c) aligning the individual candidate PET scan with the matched templates;
(d) aligning the series of brain surfaces with the candidate PET scan, wherein each of the brain surfaces aligned with the candidate PET scan includes a plurality of surface locations;
(e) selecting M templates for each of the plurality of surface locations based on a similarity measure between the candidate PET scan and a corresponding controlled PET template;
(f) computing M weights for each of the plurality of surface locations utilizing a corresponding MRI template tissue map;
(g) utilizing the M weights to combine the M templates for each of the plurality of surface locations to form an average brain surface indicator.
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Abstract
A method of determining the degree of uptake of a PET maker in an individual candidate PET scan, the method including the steps of: (a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals; (b) computing a series of brain surfaces from the matched templates; (c) aligning the individual candidate PET scan with the candidate templates; (d) aligning the candidate PET images with the series of brain surfaces; (e) selecting a predetermined (M) best candidate templates for each surface location based on a similarity measure between the candidate PET values and the corresponding controlled PET scans; (f) computing M weights for each surface location, utilizing a corresponding MRI tissue map; (g) utilizing the M weights to combine a corresponding M template tissue indicators from corresponding MRI templates into an average brain surface indicator.
14 Citations
11 Claims
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1. A method of determining the degree of uptake of a PET marker in an individual candidate PET scan, the method including the steps of:
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(a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals; (b) computing a series of brain surfaces from the matched templates; (c) aligning the individual candidate PET scan with the matched templates; (d) aligning the series of brain surfaces with the candidate PET scan, wherein each of the brain surfaces aligned with the candidate PET scan includes a plurality of surface locations; (e) selecting M templates for each of the plurality of surface locations based on a similarity measure between the candidate PET scan and a corresponding controlled PET template; (f) computing M weights for each of the plurality of surface locations utilizing a corresponding MRI template tissue map; (g) utilizing the M weights to combine the M templates for each of the plurality of surface locations to form an average brain surface indicator. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of determining the degree of uptake of an imaging marker in an individual candidate imaging marker scan, the method including the steps of:
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(a) calculating a series of representative matched controlled imaging marker scan templates and tissue marker templates for a series of controlled sample scans of individuals; (b) computing a series of internal body delineation surfaces from the matched templates; (c) aligning the individual candidate imaging marker scan with the matched templates; (d) aligning the individual candidate imaging marker scan with the series of body delineation surfaces, wherein each of the body delineation surfaces aligned with the individual candidate imaging marker scan includes a plurality of surface locations; (e) selecting M templates for each of the plurality of surface locations based on a similarity measure between the candidate imaging marker scan and a corresponding controlled imaging marker scan template; (f) computing M weights for each of the plurality of surface locations utilizing a corresponding tissue marker template; (g) utilizing the M weights to combine the M templates for each of the plurality of surface locations to form an average brain surface indicator. - View Dependent Claims (9, 10, 11)
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Specification