Nanoparticle formulations of active ingredients

• US 9,363,994 B2
• Filed: 05/30/2014
• Issued: 06/14/2016
• Est. Priority Date: 09/25/2008
• Status: Active Grant

• Current Assignee: Vive Crop Protection Inc.
• Original Assignee: Vive Crop Protection Inc.
• Inventors: Li, Fugang, Pham, Hung, Anderson, Darren J.
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): CRAIGO, WILLIAM A
• Application Number:
  US14/292,667
• Publication Number:
  US 20140287010A1
• Time in Patent Office: 746 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/28 Microcapsules or nanocapsules
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 39/04 Aryloxy-acetic acids; Derivatives thereof
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A01N 43/50 1,3-Diazoles; Hydrogenated 1,3-diazoles
• CPC Class Codes: A01N 43/54 1,3-Diazines; Hydrogenated 1,3-diazines
• CPC Class Codes: A01N 43/68 with two or three nitrogen atoms directly attached to ring carbon atoms
• CPC Class Codes: A01N 43/70 Diamino—1,3,5—triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
• CPC Class Codes: A01N 47/36 containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
• CPC Class Codes: A01N 51/00 Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
• CPC Class Codes: A01N 57/20 containing acyclic or cycloaliphatic radicals
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 2333/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C08J 2339/02 Homopolymers or copolymers of vinylamine
• CPC Class Codes: C08J 3/14 by precipitation from solutions C08J3/122 takes precedence
• CPC Class Codes: C08J 3/24 Crosslinking, e.g. vulcanising, of macromolecules mechanical aspects B29C35/00; crosslinking agents C08K
• CPC Class Codes: C08J 3/28 Treatment by wave energy or particle radiation
• CPC Class Codes: C08K 2201/011 Nanostructured additives
• CPC Class Codes: C08K 5/0058 Biocides; macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08L 25/18 : Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
• CPC Class Codes: C08L 33/02 : Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C08L 39/02 : Homopolymers or copolymers of vinylamine
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C09D 105/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

The present invention provides a composition including a polymer nanoparticle and at least one agricultural active compound incorporated with the nanoparticle, wherein the nanoparticle are less than 100 nm in diameter, and the polymer includes a polyelectrolyte.

Claims

1. A composition comprising a polymer nanoparticle and at least one organic, neutral, non-ionic agricultural compound associated with the polymer nanoparticle, wherein the polymer nanoparticle is less than 100 nm in diameter and cross-linked;

wherein the polymer nanoparticle comprises a collapsed water-soluble polyelectrolyte;

wherein the polymer has a molecular weight of at least about 100,000 Dalton prior to collapse and cross-linking; and

wherein the at least one organic, neutral, non-ionic agricultural compound is selected from the group consisting of a pyrethroid, a neonicotinoid, and combinations thereof.

2. The composition of claim 1, wherein the neonicotinoid is selected from the group consisting of imidacloprid, thiamethoxam, acetamiprid, and combinations thereof.

3. The composition of claim 2, wherein the neonicotinoid is imidacloprid.

4. The composition of claim 1, wherein the at least one organic, neutral, non-ionic agricultural compound comprises a combination of a pyrethroid and a neonicotinoid.

5. The composition of claim 4, wherein the at least one organic, neutral, non-ionic agricultural compound comprises a combination of bifenthrin and imidacloprid.

6. A composition comprising a polymer nanoparticle and a combination of at least two organic, neutral, non-ionic agricultural compounds associated with the polymer nanoparticle, wherein the polymer nanoparticle is less than 100 nm in diameter and cross-linked;

wherein the polymer nanoparticle comprises a collapsed water-soluble polyelectrolyte;

wherein the polymer has a molecular weight of at least about 100,000 Dalton prior to collapse and cross-linking; and

wherein the combination of at least two organic, neutral, non-ionic agricultural compounds comprises a combination of an insecticide and a fungicide.

7. The composition of claim 6, wherein the fungicide is a quinone-outside inhibitor selected from the group consisting of azoxystrobin, pyraclostrobin, trifloxystrobin, fluoxastrobin and combinations thereof and the insecticide is a pyrethroid or a neonicotinoid selected from the group consisting of lambda-cyhalothrin, bifenthrin, imidacloprid, and combinations thereof.