Process, arrangements and systems for providing frequency domain imaging of a sample
First Claim
1. An apparatus comprising:
- at least one source first arrangement configured to provide a radiation which includes at least one first electro-magnetic radiation directed to an anatomical sample and at least one second electro-magnetic radiation directed to a reference, wherein the anatomical sample includes at least one section, and wherein a wavelength of the radiation provided by the at least one first arrangement varies over time, and the wavelength is shorter than approximately 1150 nm;
at least one detector second arrangement configured to detect an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation; and
at least one computer third arrangement configured to generate at least one image corresponding to at least one portion of the anatomical sample using data associated with the interference.
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Accused Products
Abstract
Exemplary apparatus, arrangement and method can be provided for obtaining information associated with an anatomical structure or sample using optical microscopy. A radiation can include first electromagnetic radiation(s) directed to an anatomical sample and at least one second electromagnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength can be shorter than approximately 1150 nm. An interference can be detected between third and forth radiations associated with the first, second and fourth radiation, respectively. At least one image corresponding to portion(s) of the sample can be generated using data associated with the interference. Source arrangement(s) can be provided which is configured to provide an electromagnetic radiation having a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation(s) can be shorter than 1 millisecond, and the wavelength can be shorter than approximately 1150 nm.
525 Citations
22 Claims
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1. An apparatus comprising:
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at least one source first arrangement configured to provide a radiation which includes at least one first electro-magnetic radiation directed to an anatomical sample and at least one second electro-magnetic radiation directed to a reference, wherein the anatomical sample includes at least one section, and wherein a wavelength of the radiation provided by the at least one first arrangement varies over time, and the wavelength is shorter than approximately 1150 nm; at least one detector second arrangement configured to detect an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation; and at least one computer third arrangement configured to generate at least one image corresponding to at least one portion of the anatomical sample using data associated with the interference. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method comprising:
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causing a transmission of a radiation which includes at least one first electro-magnetic radiation directed to be provided to an anatomical sample and at least one second electro-magnetic radiation directed to a reference, wherein the anatomical sample includes at least one section, and wherein a wavelength of the radiation varies over time, and the wavelength is shorter than approximately 1150 nm; detecting an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation using detector arrangement; and generating at least one image corresponding to at least one portion of the anatomical sample using data associated with the interference.
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18. A software arrangement provided on a non-transitory computer-accessible medium and executable by a computer processing arrangement, the computer-accessible medium comprising:
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a first set of instructions which, when executed by the processing arrangement, causes a radiation which includes at least one first electro-magnetic radiation directed to be provided to an anatomical sample and at least one second electro-magnetic radiation directed to a reference, wherein the anatomical sample includes at least one section, and wherein a wavelength of the radiation varies over time, and the wavelength is shorter than approximately 1150 nm; a second set of instructions which, when executed by the processing arrangement, causes a detection of an interference between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation using a detector arrangement; and a second set of instructions which, when executed by the processing arrangement, causes the processing arrangement to generate at least one digital image corresponding to at least one portion of the anatomical sample using data associated with the interference.
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19. An apparatus comprising:
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at least one computer arrangement configured to receive first data for a three-dimensional image of at least one portion of a sample which includes at least one section, wherein the first data is associated with an optical interferometric signal generated from signals obtained from the anatomical sample and a reference, wherein the optical interferometric signal is based on a radiation whose a wavelength provided from a source arrangement varies over time, wherein the at least one computer arrangement is further configured to convert a region that is less than an entire portion of the first data to second digital data to generate a digital two-dimensional image which is associated with the at least one portion of the anatomical sample, wherein the at least one computer arrangement is still further configured to automatically select the region based on at least one characteristic of the anatomical sample, and wherein the entire portion is associated with an internal structure within the anatomical sample.
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20. An apparatus comprising:
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at least one source first arrangement providing a radiation which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, wherein a wavelength of the radiation provided by the at least one first arrangement varies over time, and wherein the anatomical sample includes at least one section; and at least one detector second arrangement configured to detect an interference signal between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation, wherein the at least one second arrangement is configured to obtain at least one signal associated with at least one phase of at least one frequency component of the interference signal over less than an entire sweep of the wavelength, and comparing the at least one phase to at least one particular information. - View Dependent Claims (21, 22)
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Specification