Deep vein thrombosis therapeutic methods using therapeutic delivery devices and systems
First Claim
1. A Deep Vein Thrombosis therapeutic method, comprising:
- providing a treatment device that includes;
a catheter having a proximal portion, a distal portion, a central lumen extending along a length of the catheter between the proximal and distal portions, and an off-set lumen extending along the length of the catheter between the proximal and distal portions; and
a balloon coupled to the distal portion of the catheter such that the balloon is in fluid communication with the off-set lumen of the catheter such that a therapeutic agent can be introduced into the balloon through the off-set lumen, wherein the therapeutic agent is configured to dissolve fibrin or thrombus present at a lesion of a vein and wherein the balloon is configured to facilitate application of the therapeutic agent from the balloon to the lesion when the balloon is positioned adjacent the lesion; and
an imaging element positioned adjacent to the balloon, wherein the imaging element includes an ultrasound element or an optical coherence tomography (OCT) element configured to image the vein;
identifying at least one venous outflow obstruction site based on images obtained from the imaging element;
assessing the at least one venous outflow obstruction site to determine whether the at least one venous outflow obstruction site causes significant narrowing of the vein, wherein venous outflow obstruction sites causing significant narrowing of the vein are identified for treatment with the therapeutic agent via the balloon;
verifying the at least one venous outflow obstruction site by determining a pressure gradient across the at least one venous outflow obstruction site; and
applying the treatment device to an identified venous outflow obstruction site of the vein of a patient to treat deep vein thrombosis symptoms of the patient, including inflating the balloon adjacent to the identified venous outflow obstruction site to apply the therapeutic agent to the identified venous outflow obstruction site to increase a cross-sectional area of a lumen of the vein.
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Accused Products
Abstract
Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Deep Vein Thrombosis or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Deep Vein Thrombosis or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient'"'"'s internal peripheral veins. In some instances, stenoses or other flow limiting structures or lesions in the patient'"'"'s affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient'"'"'s peripheral veins are provided.
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Citations
10 Claims
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1. A Deep Vein Thrombosis therapeutic method, comprising:
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providing a treatment device that includes; a catheter having a proximal portion, a distal portion, a central lumen extending along a length of the catheter between the proximal and distal portions, and an off-set lumen extending along the length of the catheter between the proximal and distal portions; and a balloon coupled to the distal portion of the catheter such that the balloon is in fluid communication with the off-set lumen of the catheter such that a therapeutic agent can be introduced into the balloon through the off-set lumen, wherein the therapeutic agent is configured to dissolve fibrin or thrombus present at a lesion of a vein and wherein the balloon is configured to facilitate application of the therapeutic agent from the balloon to the lesion when the balloon is positioned adjacent the lesion; and an imaging element positioned adjacent to the balloon, wherein the imaging element includes an ultrasound element or an optical coherence tomography (OCT) element configured to image the vein; identifying at least one venous outflow obstruction site based on images obtained from the imaging element; assessing the at least one venous outflow obstruction site to determine whether the at least one venous outflow obstruction site causes significant narrowing of the vein, wherein venous outflow obstruction sites causing significant narrowing of the vein are identified for treatment with the therapeutic agent via the balloon; verifying the at least one venous outflow obstruction site by determining a pressure gradient across the at least one venous outflow obstruction site; and applying the treatment device to an identified venous outflow obstruction site of the vein of a patient to treat deep vein thrombosis symptoms of the patient, including inflating the balloon adjacent to the identified venous outflow obstruction site to apply the therapeutic agent to the identified venous outflow obstruction site to increase a cross-sectional area of a lumen of the vein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification