Methods for treating abnormal growths in the body using a flow reducing implant

• US 9,364,354 B2
• Filed: 10/03/2014
• Issued: 06/14/2016
• Est. Priority Date: 03/27/2000
• Status: Expired due to Term

• Current Assignee: Shockwave Medical, Incorporated
• Original Assignee: Neovasc Medical Ltd. (Neovasc Incorporated)
• Inventors: Ben-Muvhar, Shmuel, Shalev, Ilan, Tsehori, Jonathan, Darvish, Nissim
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US14/506,403
• Publication Number:
  US 20150088239A1
• Time in Patent Office: 620 Days
• Field of Search: 623 115- 148
• US Class Current: 1/1
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility

Abstract

A flow reducing implant for reducing blood flow in a blood vessel having a cross sectional dimension, the flow reducing implant comprising a hollow element adapted for placement in the blood vessel defining a flow passage therethrough, said flow passage comprising at least two sections, one with a larger diameter and one with a smaller diameter, wherein said smaller diameter is smaller than a cross section of the blood vessel. A plurality of tabs anchor, generally parallel to the blood vessel wall, are provided in some embodiments of the invention.

Claims

1. An expandable flow-reducing implant for placement in a blood vessel of a patient, the implant comprising:

a narrowed section having first and second ends and defining a flow passage therethrough;

first and second flared sections located at the first and second ends of the narrowed section; and

one or more slits located on the narrowed section and the first and second flared sections,

wherein the one or more slits have a configuration that provides a greater stiffness to the narrowed section than the first and second flared sections, and wherein the one or more slits have a configuration that allows the first and second portions to expand to a diameter larger than the narrowed section.

2. The flow-reducing implant of claim 1, wherein a diameter of the flow passage is substantially fixed at a size that is predetermined prior to implantation by a configuration of the one or more slits on the narrowed section.

3. The flow-reducing implant of claim 1, wherein a configuration of the one or more slits on the first and second flared sections allow the first and second flared sections to expand within the blood vessel to a size that firmly affixes the implant within the blood vessel.

4. The flow-reducing implant of claim 1, wherein the one or more slits on the narrowed section and/or the first and second flared sections are of varying width, thickness, density, length, and/or orientation.

5. The flow-reducing implant of claim 1, wherein the one or more slits on the narrowed section and/or the first and second flared sections are of varying length.

6. The flow-reducing implant of claim 5, wherein a length of the one or more slits increases as a function of a distance from a center of the narrowed section.

7. The flow-reducing implant of claim 1, wherein the one or more slits of the first and second flared sections are on average larger than the one or more slits of the narrowed section.

8. The flow-reducing implant of claim 1, wherein the one or more slits on the narrowed section and/or the first and second flared sections are non-uniform.

9. The flow-reducing implant of claim 1, wherein the one or more slits on the narrowed section and/or the first and second flared sections are non-uniform before expansion of the first and second flared sections.

10. The flow-reducing implant of claim 1, wherein the implant is coated with a biologically inert material.

11. The flow-reducing implant of claim 1, wherein the one or more slits on the narrowed section and/or the first and second flared sections fill at least 80% of a surface of the flow-reducing implant.

12. The flow-reducing implant of claim 1, wherein the implant is coated with materials that promote tissue ingrowth.

13. The flow-reducing implant of claim 1, wherein the narrowed section is configured to decrease blood flow through the blood vessel.

14. The flow-reducing implant of claim 13, wherein the blood vessel is a coronary sinus.

15. The flow-reducing implant of claim 14, wherein the decrease in the blood flow through the coronary sinus is sufficient so as to cause angiogenesis.

16. The flow-reducing implant of claim 1, wherein at least one of the flared sections expands as a result of a balloon expansion catheter.

17. The flow-reducing implant of claim 1, wherein at least one of the flared sections expands automatically following removal of a restricting element.

18. The flow-reducing implant of claim 1, wherein the first flared section has a first diameter and the second flared section has a second diameter, wherein the first diameter is larger than the second diameter.

19. The flow-reducing implant of claim 18, wherein the first and second diameters are governed by the configuration of the one or more slits on the first and second flared sections.