Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

• US 9,364,454 B2
• Filed: 09/24/2012
• Issued: 06/14/2016
• Est. Priority Date: 10/03/2005
• Status: Active Grant

• Current Assignee: Brigham and Women's Hospital Incorporated, University of Southern California
• Original Assignee: Brigham and Women's Hospital Incorporated, University of Southern California
• Inventors: Serhan, Charles N., Petasis, Nicos A., Levy, Bruce D.
• Primary Examiner(s): Carr, Deborah D
• Application Number:
  US13/625,865
• Publication Number:
  US 20130150446A1
• Time in Patent Office: 1,359 Days
• Field of Search: 514/549, 514/560, 554/219, 554/224, 560/183, 562/587
• US Class Current: 1/1
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: C07C 59/42 containing hydroxy or O-metal groups
• CPC Class Codes: C07C 69/732 of unsaturated hydroxy carboxylic acids

Abstract

The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.

Claims

1. A purified compound of formula (I), (III), (IV), (V), or (VIII):

2. The compound of claim 1, wherein when P₁ and P₂ are both hydrogen atoms, then R is other than a hydrogen atom.

3. The compound of claim 1, wherein P₁ and P₂ are each hydrogen atoms and R is a hydrogen atom.

4. A composition comprising a compound of claim 1, and a pharmaceutically acceptable carrier.

5. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a compound of claim 1.

6. The method of claim 5, wherein P₁ and P₂ are each hydrogen atoms and R is a hydrogen atom.

7. The method of claim 5, wherein said airway inflammation is asthma.

8. The method of claim 5, wherein when P₁ and P₂ are both hydrogen atoms, then R is other than a hydrogen atom.

9. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a composition of claim 4.

10. The method of claim 9, wherein P₁ and P₂ are each hydrogen atoms and R is a hydrogen atom.

11. The method of claim 9, wherein said airway inflammation is asthma.

12. The method of claim 5, wherein P₁ and P₂ are each hydrogen atoms and R is a hydrogen atom.

13. The method of claim 5, wherein said airway inflammation is asthma.