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Treatment of cognitive disorders

  • US 9,364,497 B2
  • Filed: 09/17/2010
  • Issued: 06/14/2016
  • Est. Priority Date: 07/01/2010
  • Status: Active Grant
First Claim
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1. A method for treating mild cognitive impairment (MCI) in a subject, the method comprising administering to the subject a therapeutically effective amount of folic acid, vitamin B6 and vitamin B12, wherein:

  • the folic acid is administered in a daily amount of approximately 0.1 mg to approximately 1.5 mg;

    the vitamin B6 is administered in a daily amount of approximately 1 mg to approximately 30 mg; and

    the vitamin B12 is administered in a daily amount of approximately 0.01 mg to approximately 1.0 mg,wherein the method provides a reduction in brain atrophy by a factor of at least 2 per year compared to the absence of administration of the folic acid, vitamin B6 and vitamin B12.

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