System and method for optimized apheresis draw and return

• US 9,364,600 B2
• Filed: 01/29/2014
• Issued: 06/14/2016
• Est. Priority Date: 04/14/2008
• Status: Active Grant

• Current Assignee: Haemonetics Corporation
• Original Assignee: Haemonetics Corporation
• Inventors: Pags, Etienne, Ragusa, Michael
• Primary Examiner(s): Marcetich, Adam
• Application Number:
  US14/167,267
• Publication Number:
  US 20140148750A1
• Time in Patent Office: 867 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/024 Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount
• CPC Class Codes: A61M 1/0245 combined with blood container shaking means
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1603 Regulation parameters
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3607 Regulation parameters
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/382 Optimisation of blood component yield
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3355 : Controlling downstream pump pressure
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3393 : by weighing the reservoir

Abstract

A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.

Claims

1. A method of collecting and exchanging blood components using blood processing equipment comprising:

inserting a venous-access device into a subject, the venous-access device fluidly connected to a blood separation device;

withdrawing blood from the subject such that the drawn blood is collected in a the blood component separation device for processing;

separating the withdrawn blood into a first blood component and a second blood component using the blood component separation device;

extracting the second blood component from the blood component separation device;

returning the first blood component to the subject through a draw/return line;

measuring a first pressure within the draw/return line using a first pressure sensor, the first pressure sensor being located on the draw/return line between the venous-access device and the blood component separation device;

measuring a second pressure within the draw/return line using a second pressure sensor, the second pressure sensor being located on the draw/return line between the venous-access device and the first pressure sensor; and

controlling a flow rate within the draw/return fluid line based on a subject access pressure determined using the first pressure and the second pressure.

2. A method according to claim 1 further including introducing anticoagulant into the withdrawn blood through an anticoagulant line.

3. A method according to claim 1, wherein the blood component separation device is a centrifuge bowl.

4. A method according to claim 1, wherein the draw/return line includes a valve located between the blood component separation device and the venous-access device, the valve stopping the flow within the draw/return line.

5. A method according to claim 1, wherein the subject access pressure is further determined using at least one characteristic of a first portion of the draw/return line and at least one characteristic of a second portion of the draw/return line, wherein the first portion is between the first and second pressure sensors and the second portion is between the second pressure sensor and the venous-access device.

6. A method according to claim 5, wherein the at least one characteristic of the first portion of the draw/return line and the at least one characteristic of the second portion of the draw/return line are selected from the group consisting of length, inner diameter, and materials of construction.

7. A method according to claim 5, wherein the flow rate is also controlled based on a first flow resistance within the first portion of the draw/return line, the first flow resistance calculated based on the at least one characteristic of the first portion of the draw/return line.

8. A method according to claim 5, wherein the flow rate is further controlled based on a second flow resistance within the second portion of the draw/return line, the second flow resistance calculated based on the at least one characteristic of the second portion of the draw/return line.

9. A method according to claim 1, wherein the blood component separation device further separates the drawn blood into a third blood component in addition to the first blood component and the second blood component.

10. A method according to claim 9, wherein the first blood component is red blood cells, the second blood component is platelets, and the third blood component is plasma.

11. A method according to claim 1, wherein the subject access pressure is determined in real-time.

12. A method according to claim 1, wherein the flow rate is at least one of a draw flow rate and a return flow rate.