Antibodies that bind to repulsive guidance molecule A (RGMA)
First Claim
Patent Images
1. An isolated antibody, the antibody comprising:
- (a) a variable heavy domain comprising a complementarity-determining region (CDR) 1 comprising an amino acid sequence as set forth in SEQ ID NO;
2, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
3, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
4, and a variable light domain comprising a CDR1 comprising an amino acid sequence as set forth in SEQ ID NO;
6, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
7, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
73;
or(b) a light chain variable amino acid sequence as set forth in SEQ ID NO;
146 and a heavy chain variable amino acid sequence as set forth in SEQ ID NO;
147wherein the antibody binds to Repulsive Guidance Molecule a (RGMa).
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Abstract
Provided herein are antibodies that bind to Repulsive Guidance Molecule a (RGMa) and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
274 Citations
13 Claims
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1. An isolated antibody, the antibody comprising:
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(a) a variable heavy domain comprising a complementarity-determining region (CDR) 1 comprising an amino acid sequence as set forth in SEQ ID NO;
2, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
3, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
4, and a variable light domain comprising a CDR1 comprising an amino acid sequence as set forth in SEQ ID NO;
6, a CDR2 comprising an amino acid sequence as set forth in SEQ ID NO;
7, and a CDR3 comprising an amino acid sequence as set forth in SEQ ID NO;
73;
or(b) a light chain variable amino acid sequence as set forth in SEQ ID NO;
146 and a heavy chain variable amino acid sequence as set forth in SEQ ID NO;
147wherein the antibody binds to Repulsive Guidance Molecule a (RGMa). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification