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Soluble heavy-chain only antibodies

  • US 9,365,655 B2
  • Filed: 03/15/2013
  • Issued: 06/14/2016
  • Est. Priority Date: 03/24/2009
  • Status: Active Grant
First Claim
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1. A transgenic non-human mammal comprising a transgene, the transgene comprising at least one heterologous immunoglobulin heavy chain locus comprising human VH gene segments, one or more human D gene segments, human J gene segments, and at least one mouse constant region gene segment wherein the human VH gene segments comprise up to 20 VH gene segments and all of said human VH gene segments are naturally occurring, the human D gene segments comprise at least 5 human D gene segments, the human J gene segments comprise all six human J gene segments, and the mouse constant region gene segment comprises a Cγ

  • lacking CH1.

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