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Ultrasound based antigen binding detection

  • US 9,370,321 B2
  • Filed: 06/25/2012
  • Issued: 06/21/2016
  • Est. Priority Date: 06/25/2012
  • Status: Expired due to Fees
First Claim
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1. An endoscopic ultrasound probe comprising:

  • a piezoelectric wafer;

    at least one antibody immobilized on the piezoelectric wafer;

    an electrode transducer on a needle, the piezoelectric wafer being stacked on the electrode transducer;

    the endoscopic ultrasound probe being configured to apply an ultrasound energy to the piezoelectric wafer to create a vibration in the piezoelectric wafer; and

    the electrode transducer being configured to detect an electrical signal generated by the piezoelectric wafer in response to the vibration in the piezoelectric wafer and transmit the detected electric signal to a recording device for the detection of a change in the vibration in the piezoelectric wafer due to binding of an antigen to the antibody immobilized on the piezoelectric wafer.

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