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Hydrogel polymeric compositions and methods

  • US 9,370,485 B2
  • Filed: 08/27/2014
  • Issued: 06/21/2016
  • Est. Priority Date: 07/09/2007
  • Status: Active Grant
First Claim
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1. A method of treating an ophthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a site in an eye, wherein the hydrogel, when formed, has a volume of less than 0.5 ml and comprises a hydrophobic particle entrapped as a suspension within the hydrogel, the particle comprising a therapeutic agent that is released into the eye to treat the ophthalmic disease, wherein a time at which a cumulative 80% w/w of the therapeutic agent has been released is between about 14 and 120 days.

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