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Dextran-based polymer tissue adhesive for medical use

  • US 9,370,601 B2
  • Filed: 08/21/2014
  • Issued: 06/21/2016
  • Est. Priority Date: 11/14/2007
  • Status: Active Grant
First Claim
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1. A method for applying a coating to an anatomical site on tissue of a living organism comprising:

  • applying to the sitea) at least one dextran that has been derivatized to provide at least one aminodextran that contains primary amine groups, said at least one dextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said at least one aminodextran having an amine substitution level of about 5% to about 65%;

    followed byb) at least one dextran that has been oxidized to provide at least one oxidized dextran containing aldehyde groups, said at least one dextran having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said at least one oxidized dextran having an equivalent weight per aldehyde group of about 65 to about 1500 Daltons;

    or applying (b) followed by (a) and mixing (a) and (b) on the site;

    or premixing (a) and (b) and applying the resulting mixture to the site.

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