Planar implant

• US 9,370,604 B2
• Filed: 07/23/2008
• Issued: 06/21/2016
• Est. Priority Date: 07/24/2007
• Status: Active Grant

• Current Assignee: Aesculap AG (Lonza Group AG)
• Original Assignee: Aesculap AG (Lonza Group AG)
• Inventors: Odermatt, Erich, Wegmann, Juergen, Blender, Bernd
• Primary Examiner(s): Ou, Jung
• Application Number:
  US12/177,996
• Publication Number:
  US 20090054995A1
• Time in Patent Office: 2,890 Days
• Field of Search: 623/15.12, 623 2371- 2376, 623/915, 623/918, 623/925, 606/213
• US Class Current: 1/1
• CPC Class Codes: A61F 13/00 Bandages or dressings radioactive dressings A61N5/1029; Absorbent pads
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61L 26/0033 Collagen
• CPC Class Codes: A61L 26/0038 Gelatin
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3675 Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges

Abstract

A planar implant for replacement of biological tissues includes a layered structure including

a) a lyophilized pericardium layer of biological origin, and

b) at least one sponge-like layer of lyophilized extracellular protein.

Claims

1. A planar implant for replacement of biological tissues consisting of a layered structure consisting of:

a) a lyophilized pericardium layer of biological origin, wherein the pericardium layer constitutes an impenetrable liquid barrier, and wherein the pericardium layer has a weight per unit area of 50 to 180 g/m², and

b) at least one sponge layer of lyophilized extracellular protein which is free of crosslinking agents,

wherein the implant has a thickness of 1 to 10 mm, a weight per unit area of 80 to 480 g/m² and the implant is configured to replace and/or close the dura mater.

2. The planar implant according to claim 1, wherein the extracellular protein is collagen.

3. The planar implant according to claim 1, wherein the extracellular protein is gelatin.

4. The planar implant according to claim 1, wherein the pericardium layer is covered on one side with the sponge layer.

5. The planar implant according to claim 1, wherein a surface of the pericardium layer directed toward the sponge layer is roughened.

6. The planar implant according to claim 1, wherein the sponge layer is lyophilized as substrate onto the pericardium layer.

7. The planar implant according to claim 1, wherein the sponge layer is fixed to the pericardium layer.

8. The planar implant according to claim 1, wherein the pericardium layer has a thickness of 0.1 to 4 mm.

9. The planar implant according to claim 1, wherein the sponge layer has a weight per unit area of 30 to 300 g/m².

10. The planar implant according to claim 1, wherein the sponge layer is formed only partially on the pericardium layer.

11. The planar implant according to claim 1, wherein the sponge layer has a pH value of <

4 upon addition of water.

12. The planar implant according to claim 1, wherein the sponge layer has a liquid absorption capacity corresponding to 20 to 60 times its own weight.

13. The planar implant according to claim 1, wherein the sponge layer can be completely wetted with water within a period of <

100 seconds.

14. A planar implant for replacement of biological tissues consisting of a layered structure consisting of:

a) a lyophilized pericardium layer of bovine origin, wherein the pericardium layer constitutes an impenetrable liquid barrier and has a weight per unit area of 50 to 180 g/m², and

b) at least one sponge layer of lyophilized collagen of bovine origin which is free of crosslinking agents, wherein the sponge layer has a weight per unit area of 30 to 300 g/m², a liquid absorption capacity corresponding to 20 to 60 times its own weight, and is configured to be wetted with water with a period of <

100 seconds,

wherein the implant has a thickness of 1 to 10 mm, a weight per unit area of 80 to 480 g/m² and is configured to replace and/or close the dura mater.

15. A planar implant for replacement of biological tissues consisting of a layered structure consisting of:

a) a lyophilized pericardium layer of bovine origin, wherein the pericardium layer constitutes an impenetrable liquid barrier, and has a weight per unit area of 50 to 180 g/m²,

b) at least one sponge layer of a lyophilized suspension of collagen of bovine origin which is free of cross-linking agents and contains at least one water-soluble biocompatible organic acid, wherein the sponge layer has a weight per unit area of 30 to 300 g/m², a liquid absorption capacity corresponding to 20 to 60 times its own weight, and is configured to be wetted with water with a period of <

100 seconds,

wherein the implant has a thickness of 1 to 10 mm, a weight per unit area of 80 to 480 g/m² and is configured to replace and/or close the dura mater.