Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith
First Claim
Patent Images
1. A composition comprising:
- a continuous matrix formed of a polypeptide crosslinked with a second polymer; and
particles of a porous, osteoconductive material dispersed in the continuous matrix;
wherein the pores of the osteoconductive material have adsorbed therein a biocompatible material.
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Accused Products
Abstract
The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.
45 Citations
26 Claims
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1. A composition comprising:
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a continuous matrix formed of a polypeptide crosslinked with a second polymer; and particles of a porous, osteoconductive material dispersed in the continuous matrix; wherein the pores of the osteoconductive material have adsorbed therein a biocompatible material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A kit comprising:
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one or more containers containing a composition comprising a continuous matrix formed of a polypeptide crosslinked with a second polymer and particles of a porous, osteoconductive material dispersed in the continuous matrix, wherein the pores of the osteoconductive material have adsorbed therein a biocompatible material; and an instruction set directed to a health care provider describing steps for administering the composition to a bone void in an amount effective for regenerating bone in the void.
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25. A composition comprising:
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a continuous matrix formed of a polypeptide crosslinked with a second polymer; and particles of a porous, osteoconductive material dispersed in the continuous matrix; wherein the pores of the osteoconductive material have adsorbed therein a polypeptide that is the same polypeptide that is crosslinked with the second polymer.
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26. A composition comprising:
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a continuous matrix formed of a polypeptide crosslinked with a second polymer; and particles of a porous, osteoconductive material dispersed in the continuous matrix; wherein the pores of the osteoconductive material have adsorbed therein a biocompatible material, and one or more of the following conditions are met; the particles of the porous, osteoconductive material have an average diameter of about 1μ
m to about 3,000 μ
m;the particles of the porous, osteoconductive material have a mean pore diameter (volume) of about 100μ
m to about 450 μ
m;the particles of the porous, osteoconductive material have a mean pore diameter (area) of about 20μ
m to about 60μ
m;the particles of the porous, osteoconductive material have a porosity of about 35% or greater; the particles of the porous, osteoconductive material have a surface area of about 1m2/g or greater; the particles of the porous, osteoconductive material are amorphous with interconnecting pores; the particles of the porous, osteoconductive material and the continuous matrix are present in a dry weight ratio of about 90;
10 to about 50;
50;the composition is dehydrated.
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Specification
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- Resources
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Current AssigneeXtant Medical Holdings, Inc. (OrbiMed Advisors LLC (China))
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Original AssigneeRTI Surgical Incorporated
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InventorsLamberti, Francis Vincent, Hill, Ronald Stewart, MacMillan, Adam, Ahn, Edward, Schlossberg, Brian, Capistron, Stephen, Lloyd, William H.
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Primary Examiner(s)AZPURU, CARLOS A
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Application NumberUS14/568,339Publication NumberTime in Patent Office557 DaysField of SearchUS Class Current1/1CPC Class CodesA61K 9/0024 Solid, semi-solid or solidi...A61L 2300/112 Phosphorus-containing compo...A61L 2400/06 Flowable or injectable impl...A61L 2430/02 for reconstruction of bones...A61L 27/22 Polypeptides or derivatives...A61L 27/40 Composite materials, i.e. c...A61L 27/46 with phosphorus-containing ...A61L 27/48 with macromolecular fillersA61L 27/54 Biologically active materia...A61L 27/56 Porous materials, e.g. foam...A61L 27/58 Materials at least partiall...C08L 5/02 Dextran; Derivatives thereofC08L 89/00 Compositions of proteins; C...
