Methods and systems for controlling blood pressure by controlling atrial pressure

• US 9,370,662 B2
• Filed: 06/17/2014
• Issued: 06/21/2016
• Est. Priority Date: 12/19/2013
• Status: Active Grant

• Current Assignee: Backbeat Medical, LLC
• Original Assignee: Backbeat Medical, Inc.
• Inventors: Mika, Yuval, Sherman, Darren, Schwartz, Robert S., Van Tassel, Robert A., Burkhoff, Daniel
• Primary Examiner(s): Layno, Carl H.
• Assistant Examiner(s): Morales, Jon Eric C
• Application Number:
  US14/427,478
• Publication Number:
  US 20150360035A1
• Time in Patent Office: 735 Days
• Field of Search: 607/17
• US Class Current: 1/1
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2250/0013 for adjusting fluid pressure
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

Claims

1. A method, carried out with an implanted heart muscle stimulator associated with a heart of a patient, for reducing blood pressure of the patient, the method comprising:

delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of the heart of the patient,

wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting,

wherein at least one of the first stimulation setting and the second stimulation setting is configured to reduce or prevent atrial kick, and

wherein stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick are delivered based upon need.

2. The method of claim 1, wherein the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick are provided only during part of a 24-hour period.

3. The method of claim 2, wherein said part of a 24-hour period is a night or part thereof.

4. The method of claim 2, wherein said part of a 24-hour period is a day or part thereof.

5. The method of claim 1, wherein the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick are provided only when heart rate is below a predefined threshold.

6. The method of claim 5, wherein the predefined threshold is an absolute value.

7. The method of claim 6, wherein the absolute value is 90 bpm.

8. The method of claim 5, wherein the predefined threshold is set at a value relative to the patient'"'"'s average heart rate.

9. The method of claim 8, wherein the predefined threshold is at least one of 30 beats above average heart rate and above the 80^th percentile of the heart rate.

10. The method of claim 1, wherein the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick are provided only when the patient is at rest or at a low activity level.

11. The method of claim 10, further comprising determining whether the patient is at rest or at a low activity level by sensing at least one of motion, posture, respiration rate, and heart rate.

12. The method of claim 1, wherein the one or more stimulation patterns are selected based on a measured blood pressure parameter.

13. The method of claim 12, further comprising changing the one or more stimulation patterns when baroreflex is sensed.

14. A system for reducing blood pressure of a patient, the system comprising:

a stimulation circuit configured to deliver one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of the heart of the patient; and

at least one controller configured to execute the delivery of the one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber,

wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting,

wherein at least one of the first stimulation setting and the second stimulation setting is configured to reduce or prevent atrial kick, and

wherein stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick are delivered based upon need.

15. The system of claim 14, wherein the at least one controller is configured to deliver the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick, only during part of a 24-hour period.

16. The system of claim 15, wherein said part of a 24-hour period is a night or part thereof.

17. The system of claim 15, wherein said part of a 24-hour period is a day or part thereof.

18. The system of claim 14, wherein the at least one controller is configured to deliver the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick, only when heart rate is below a predefined threshold.

19. The system of claim 18, wherein the predefined threshold is an absolute value.

20. The system of claim 19, wherein the absolute value is 90 bpm.

21. The system of claim 18, wherein the predefined threshold is set at a value relative to the patient'"'"'s average heart rate.

22. The system of claim 21, wherein the predefined threshold is at least one of 30 beats above average heart rate and above the 80^th percentile of the heart rate.

23. The system of claim 14, wherein the at least one controller is configured to deliver the stimulation pulses having a stimulation setting configured to reduce or prevent atrial kick, only when the patient is at rest or at a low activity level.

24. The system of claim 23, wherein the system is configured to determine whether the patient is at rest or at a low activity level by sensing at least one of motion, posture, respiration rate, and heart rate.

25. The system of claim 14, wherein the at least one controller is configured to select the one or more stimulation patterns based on a measured blood pressure parameter.

26. The system of claim 25, wherein the at least one controller is configured to change the one or more stimulation patterns when baroreflex is sensed.

27. A method for adjusting a pulse setting in a system for controlling blood pressure, the method comprising:

receiving atrial pressure data associated with an atrium of a heart of a patient during at least one cardiac cycle, wherein the atrial pressure data results from the system'"'"'s delivering to the heart a stimulation pulse having a first pulse setting;

analyzing said atrial pressure data; and

providing an adjusted second pulse setting according to said analysis, wherein the adjusted second pulse setting is different from the first pulse setting.

28. The method of claim 27, wherein said analyzing comprises analyzing the atrial pressure data to estimate an overlap in time between an atrial pressure resulting from atrial contraction and a passive pressure build-up of the atrium.

29. The method of claim 28, wherein said analyzing comprises analyzing the atrial pressure data to estimate an overlap in time between a maximum atrial pressure resulting from atrial contraction and a maximum passive pressure build-up of the atrium.

30. The method of claim 28, further comprising comparing the atrial pressure data resulting from the stimulation pulse to atrial pressure data received without the stimulation pulse.

31. The method of claim 27, wherein said analyzing comprises plotting the atrial pressure data.

32. The method of claim 27, wherein said analyzing comprises mathematically analyzing the atrial pressure data.