Benzoimidazol-2-yl pyrimidine derivatives

• US 9,371,311 B2
• Filed: 08/14/2014
• Issued: 06/21/2016
• Est. Priority Date: 06/30/2008
• Status: Active Grant

• Current Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Mani, Neelakandha S., Mapes, Christopher L., Pippel, Daniel J., Broggini, Diego F.
• Primary Examiner(s): Wilson, James O
• Assistant Examiner(s): Sackey, Ebenezer O
• Application Number:
  US14/460,243
• Publication Number:
  US 20140357865A1
• Time in Patent Office: 677 Days
• Field of Search: 544/331
• US Class Current: 1/1
• CPC Class Codes: C07B 2200/13 Crystalline forms, e.g. polymorphs
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond

Abstract

The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H₄ receptor modulators and processes for the preparation of such compounds.

Claims

1. A crystalline hemi-tartrate of compound of formula (I-A)