Extended recombinant polypeptides and compositions comprising same
First Claim
Patent Images
1. An isolated extended recombinant polypeptide (XTEN) comprising an amino acid sequence which has at least 90% sequence identity to a sequence selected from the group consisting of SEQ ID NOS:
- 204, 206, 210, 213, 216-219, 373-409, 684-698, 700-716, 762-769, 771, 774, and 777-780 wherein the XTEN comprises a motif selected from the group consisting of SEQ ID NO;
186, SEQ ID NO;
187, SEQ ID NO;
188, and SEQ ID NO;
189.
4 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
216 Citations
37 Claims
-
1. An isolated extended recombinant polypeptide (XTEN) comprising an amino acid sequence which has at least 90% sequence identity to a sequence selected from the group consisting of SEQ ID NOS:
- 204, 206, 210, 213, 216-219, 373-409, 684-698, 700-716, 762-769, 771, 774, and 777-780 wherein the XTEN comprises a motif selected from the group consisting of SEQ ID NO;
186, SEQ ID NO;
187, SEQ ID NO;
188, and SEQ ID NO;
189. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 22, 23, 24, 25, 26, 27, 29)
- 204, 206, 210, 213, 216-219, 373-409, 684-698, 700-716, 762-769, 771, 774, and 777-780 wherein the XTEN comprises a motif selected from the group consisting of SEQ ID NO;
-
20. An isolated fusion protein comprising a sequence that has at least 90% sequence identity to a sequence selected from SEQ ID NOS:
- 807-808, 812, 815, 818-819, 827-828, 832, 835, 838-841, 845-846, 850, 853, 856-857, 861-862, 866, 869, 872-875, 879-880, 884-885, 888, 891-892, 896-897, 901-902, 905, 908-911, 915-916, 920, 923, 926-927, 931-932, 936, 939, 942-945, 949-950, 954, 957, 960-961, 965-966, 970, 973, 976-979, 983-984, 988, 991, 994-995, 999-1000, 1004, 1007, 1010-1013, 1017-1018, 1022, 1025, 1028-1029, 1033-1034, 1038, 1041, 1044-1047, 1051-1052, 1056, 1059, 1062-1063, 1067-1068, 1072, 1075, 1078-1081, 1085-1086, 1090, 1093, 1096-1097, 1100-1101, 1105, 1108, 1111-1114, 1118-1119, 1123, 1126, 1129-1130, 1133-1134, 1138, 1141, 1144-1147, 1151-1152, 1156, 1159, 1162-1163, 1167-1168, 1172, 1175, 1178-1181, 1185-1186, 1190, 1193, 1196-1197, 1201-1202, 1206, 1209, 1212-1215, 1219-1220, 1224, 1227, 1230-1231, 1235-1236, 1240, 1243, 1246-1249, 1253-1254, 1258, 1261, 1264-1265, 1269-1270, 1274, 1277, 1280-1283, 1287-1288, 1292, 1295, 1298-1299, 1303-1304, 1308, 1311, 1314-1317, 1321-1322, 1326, 1329, 1332-1333, 1337-1338, 1342, 1345, 1348-1351, 1355-1356, 1360, 1363, 1366-1367, 1371-1372, 1376, 1379, 1382-1385, 1389-1390, 1394, 1397, 1400-1401, 1405-1406, 1410, 1413, 1416-1419, 1423-1424, 1428, 1431, 1434-1435, 1439-1440, 1444, 1447, 1450-1453, 1457-1458, 1462, 1465, 1467-1468, 1472, 1475, 1478-1479, 1483-1484, 1488, 1491, 1494-1495, 1498-1499, 1503-1504, 1508, 1511, 1514-1517, 1521-1522, 1526, 1529, 1532-1533, 1537-1538, 1542, 1545, 1548-1551, 1555-1556, 1560, 1563, 1566-1567, 1571-1572, 1576, 1579, 1582-1585, 1589-1590, 1594, 1597, 1600-1601, 1605-1606, 1610, 1613, 1616-1619, 1623-1624, 1628, 1631, 1634-1635, 1639-1640, 1644, 1647, 1650-1653, 1657-1658, 1662, 1665, 1668-1669, 1673-1674, 1678, 1681, 1684-1687, 1690-1697, 1699-1703, 1705-1707, 1779-1784, 1786-1787, 1790-1792, 1795-1797, 1800-1801, 1804-1805, 1807-1818.
- View Dependent Claims (21, 30, 31, 32, 33, 34, 35, 36, 37)
-
28. The host cell of claim wherein the host cell is E. coli.
Specification