Systems and methods for model-based estimation of cardiac output and total peripheral resistance

• US 9,375,160 B2
• Filed: 09/10/2012
• Issued: 06/28/2016
• Est. Priority Date: 05/16/2007
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Parlikar, Tushar A., Ranade, Gireeja V., Heldt, Thomas, Verghese, George C.
• Primary Examiner(s): BERHANU, ETSUB D
• Application Number:
  US13/607,924
• Publication Number:
  US 20130006127A1
• Time in Patent Office: 1,387 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence

Abstract

The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in arterial blood pressure and estimating from the variability a time constant for a lumped parameter beat-to-beat averaged Windkessel model of the arterial tree. Uncalibrated cardiac output and uncalibrated total peripheral resistance may then be calculated from the time constant. Calibrated cardiac output and calibrated total peripheral resistance may be computed using calibration data, assuming an arterial compliance that is either constant or dependent on mean arterial blood pressure. The parameters of the arterial compliance may be estimated in a least-squares manner.

Claims

1. A system for displaying information about cardiac output and/or total peripheral resistance, comprising:

a display;

a processor; and

a memory storing computer-executable instructions which, when executed by the processor, cause the processor to;

process two or more cycles of arterial blood pressure information to determine a mean arterial blood pressure over each cycle beginning at a beat onset time and an inter-beat variability in blood pressure between the two or more cycles,

compute time series of estimates of cardiac output and/or total peripheral resistance based on the mean arterial blood pressures, the inter-beat variability, and a computational model of an arterial tree, and

cause the display of the time series of estimates.

2. The system of claim 1, wherein at least two time series of estimates are computed, corresponding to cardiac output and total peripheral resistance, and at least two of the time series of estimates are displayed simultaneously.

3. The system of claim 1, wherein the time series of estimates are updated as additional arterial blood pressure information is received.

4. The system of claim 3, wherein the time series of estimates are updated beat-to-beat.

5. The system of claim 1, wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

cause the display of one or more time series of drug infusion information.

6. The system of claim 5, wherein the one or more time series of drug infusion information and the time series of estimates are displayed simultaneously.

7. The system of claim 1, wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

compute an alternate time series of estimates of cardiac output and/or total peripheral resistance using an alternate computational model, the alternate computational model different from the computational model of the arterial tree; and

cause the display of information about the difference between the alternate time series of estimates and the time series of estimates.

8. The system of claim 1, wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

receive a time series of measurements of cardiac output and/or total peripheral resistance; and

cause the display of information about the difference between the time series of measurements and the time series of estimates.

9. The system of claim 8, wherein causing the display of information about the difference between the time series of measurements and the time series of estimates comprises causing the display of the time series of measurements simultaneously with the display of the time series of estimates.

10. A computer-implemented method for displaying information about cardiac output and/or total peripheral resistance, comprising:

processing two or more cycles of arterial blood pressure information to determine a mean arterial blood pressure over each cycle beginning at a beat onset time and an inter-beat variability in blood pressure between the two or more cycles;

computing time series of estimates of each of cardiac output and/or total peripheral resistance based on the mean arterial blood pressures, the inter-beat variability, and a computational model of an arterial tree; and

causing the display of the time series of estimates.

11. The computer-implemented method of claim 10, wherein at least two time series of estimates are computed, corresponding to cardiac output and total peripheral resistance, and at least two of the time series of estimates are displayed simultaneously.

12. The computer-implemented method of claim 10, wherein the time series of estimates are updated as additional arterial blood pressure information is received.

13. The computer-implemented method of claim 12, wherein the time series of estimates are updated beat-to-beat.

14. The computer-implemented method of claim 10, further comprising:

causing the display of one or more time series of drug infusion information.

15. The computer-implemented method of claim 14, wherein the one or more time series of drug infusion information and the time series of estimates are displayed simultaneously.

16. The computer-implemented method of claim 10, further comprising:

computing an alternate time series of estimates of cardiac output and/or total peripheral resistance using an alternate computational model, the alternate computational model different from the computational model of the arterial tree; and

causing the display of information about the difference between the alternate time series of estimates and the time series of estimates.

17. The computer-implemented method of claim 10, further comprising:

receiving a time series of measurements of cardiac output and/or total peripheral resistance; and

causing the display of information about the difference between the time series of measurements and the time series of estimates.

18. The computer-implemented method of claim 17, wherein causing the display of information about the difference between the time series of measurements and the time series of estimates comprises causing the display of the time series of measurements simultaneously with the display of the time series of estimates.