Systems and methods for model-based estimation of cardiac output and total peripheral resistance
First Claim
1. A system for displaying information about cardiac output and/or total peripheral resistance, comprising:
- a display;
a processor; and
a memory storing computer-executable instructions which, when executed by the processor, cause the processor to;
process two or more cycles of arterial blood pressure information to determine a mean arterial blood pressure over each cycle beginning at a beat onset time and an inter-beat variability in blood pressure between the two or more cycles,compute time series of estimates of cardiac output and/or total peripheral resistance based on the mean arterial blood pressures, the inter-beat variability, and a computational model of an arterial tree, andcause the display of the time series of estimates.
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Accused Products
Abstract
The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in arterial blood pressure and estimating from the variability a time constant for a lumped parameter beat-to-beat averaged Windkessel model of the arterial tree. Uncalibrated cardiac output and uncalibrated total peripheral resistance may then be calculated from the time constant. Calibrated cardiac output and calibrated total peripheral resistance may be computed using calibration data, assuming an arterial compliance that is either constant or dependent on mean arterial blood pressure. The parameters of the arterial compliance may be estimated in a least-squares manner.
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Citations
18 Claims
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1. A system for displaying information about cardiac output and/or total peripheral resistance, comprising:
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a display; a processor; and a memory storing computer-executable instructions which, when executed by the processor, cause the processor to; process two or more cycles of arterial blood pressure information to determine a mean arterial blood pressure over each cycle beginning at a beat onset time and an inter-beat variability in blood pressure between the two or more cycles, compute time series of estimates of cardiac output and/or total peripheral resistance based on the mean arterial blood pressures, the inter-beat variability, and a computational model of an arterial tree, and cause the display of the time series of estimates. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A computer-implemented method for displaying information about cardiac output and/or total peripheral resistance, comprising:
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processing two or more cycles of arterial blood pressure information to determine a mean arterial blood pressure over each cycle beginning at a beat onset time and an inter-beat variability in blood pressure between the two or more cycles; computing time series of estimates of each of cardiac output and/or total peripheral resistance based on the mean arterial blood pressures, the inter-beat variability, and a computational model of an arterial tree; and causing the display of the time series of estimates. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification