Immobilized biologically active entities having high biological activity following mechanical manipulation
First Claim
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1. A medical device comprising:
- a medical device that is capable of being compacted and expanded;
a polymeric substrate material, wherein said polymeric substrate material is fluoropolymeric in composition;
a polymeric covering material attached to at least a portion of a surface of said substrate material;
a first plurality of heparin molecules having anti-thrombin Ill binding activity end point attached to at least a portion of said polymeric covering material; and
a composition comprising a second plurality of heparin molecules non-covalently combined with said first plurality of heparin molecules,wherein said first plurality of heparin molecules have an anti-thrombin Ill binding activity of at least 100 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material when measured following compaction of said medical device to 50% of said medical device'"'"'s original size and expansion of said medical device.
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Abstract
The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
57 Citations
4 Claims
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1. A medical device comprising:
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a medical device that is capable of being compacted and expanded; a polymeric substrate material, wherein said polymeric substrate material is fluoropolymeric in composition; a polymeric covering material attached to at least a portion of a surface of said substrate material; a first plurality of heparin molecules having anti-thrombin Ill binding activity end point attached to at least a portion of said polymeric covering material; and a composition comprising a second plurality of heparin molecules non-covalently combined with said first plurality of heparin molecules, wherein said first plurality of heparin molecules have an anti-thrombin Ill binding activity of at least 100 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material when measured following compaction of said medical device to 50% of said medical device'"'"'s original size and expansion of said medical device. - View Dependent Claims (2, 3, 4)
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Specification