Apparatus and method of reacting polymers by exposure to UV radiation to produce injectable medical devices

• US 9,375,699 B2
• Filed: 02/22/2010
• Issued: 06/28/2016
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sbastien
• Primary Examiner(s): MCCLENDON, SANZA L
• Application Number:
  US13/202,345
• Publication Number:
  US 20120041095A1
• Time in Patent Office: 2,318 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: B01J 19/123 Ultraviolet light
• CPC Class Codes: B01J 2219/0888 Liquid-liquid

Abstract

Cross-linked compositions include a first precursor functionalized with a first reactive member and a second precursor functionalized with a second reactive member, the first and second reactive members covalently bonding with each other when exposed to UV radiation. The compositions are useful in a variety of surgical and wound treatment applications.

Claims

1. An apparatus comprising:

a supply assembly configured to maintain and selectively dispense a first precursor functionalized with a first click reactive member and a second precursor functionalized with a second click reactive member, the first and second click reactive members capable of covalently bonding with each other

a mixing assembly configured to mix the first and second precursors in a mixing cavity, and,

at least one source of UV radiation positioned to irradiate the mixed first and second precursors within the mixing assembly, wherein the at least one source of UV radiation comprises a mixing element comprising a lamp which extends longitudinally through the mixing assembly and the mixing element further includes blades extending radially outward along a length of the lamp.

2. The apparatus of claim 1 wherein the mixing element extends an entire length of the mixing cavity.

3. The apparatus of claim 2 wherein the lamp is supported on a proximal and distal end by supports configured to maintain the lamp within the mixing cavity while per ing the first and second precursors through the mixing cavity.

4. The apparatus of claim 1 wherein the mixing assembly further comprises a coating on at least a portion thereof, the coating comprising a material capable of reflecting UV radiation from the at least one source of UV radiation within the mixing assembly.

5. The apparatus of claim 1 wherein the mixing assembly comprises an elongate member having a proximal end and a distal end with the mixing cavity extending therebetween.

9. The apparatus of claim 1, wherein the first and second precursor each possess a core made of a biocompatible material.

10. The apparatus of claim 1, wherein the first precursor and optionally the second precursor comprises a polyol core.

11. The apparatus of claim 10, wherein the polyol is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

12. The apparatus of claim 1, wherein the first click reactive member is a thiol group and the second click reactive member is an alkene group.

13. The apparatus of claim 1, wherein the mixing assembly further comprises protrusions extending radially into the mixing cavity to assist in the mixing of first and second precursors.

6. An apparatus comprising:

a supply assembly configured to maintain and selectively dispense a first precursor functionalized with a first click reactive member and a second precursor functionalized with a second click reactive member, the first and second click reactive members capable of covalently bonding with each other,

a mixing assembly comprising an elongate member having a proximal end, a distal end and a mixing cavity extending therebetween, the mixing assembly configured to mix the first and second precursors in the mixing cavity, and

a source of UV radiation positioned to irradiate the mixed first and second precursors within the mixing assembly, wherein the source of UV radiation comprises a plurality of lamps mounted within the elongate member and extending along at least a portion of the mixing cavity.

7. The apparatus of claim 6 further comprising a plurality of mixing elements which form substantially helical members.

8. The apparatus of claim 7 wherein the plurality of mixing elements are arranged in an alternating orientation.

14. The apparatus of claim 6, wherein the lamps comprise an annular configuration.