Fluid transfer device

• US 9,376,224 B2
• Filed: 01/16/2014
• Issued: 06/28/2016
• Est. Priority Date: 05/04/2009
• Status: Active Grant

• Current Assignee: Mannkind Corporation
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: Gonnelli, Robert R., Standley, Robert L., Levesque, Steven F.
• Primary Examiner(s): MAUST, TIMOTHY LEWIS
• Application Number:
  US14/156,514
• Publication Number:
  US 20140124092A1
• Time in Patent Office: 894 Days
• Field of Search: 141 25- 27, 141/319, 141/322, 141/329, 141/330, 604/407, 604/414
• US Class Current: 1/1
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2017 having three or more piercing ends
• CPC Class Codes: A61J 1/2037 having valve means
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2072 for internal venting
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: B65B 3/26 Methods or devices for controlling the quantity of the material fed or filled
• CPC Class Codes: G01F 11/262 for liquid or semi-liquid
• CPC Class Codes: Y10T 137/8593 Systems

Abstract

A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir includes a metering reservoir and a manifold that forms at least part of a first channel that is fluidly connected with the metering reservoir. The first channel comprises a first cannula extending from the manifold. The manifold forms at least part of a second channel fluidly connected with the metering reservoir. The second channel comprises a second cannula extending from the manifold. A third channel extends through the manifold and comprises a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula. A first check valve is disposed within the first channel and a second check valve is disposed within the second channel.

Claims

1. A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir comprising:

a metering reservoir;

a first flow path having a first one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the supply reservoir and the metering reservoir and a second one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the fill reservoir and the metering reservoir; and

a second flow path configured to fluidly couple the supply reservoir and the fill reservoir,

wherein expanding the metering reservoir draws fluid from the supply reservoir via the first one-way channel into the metering reservoir, compressing the metering reservoir expels the fluid from the metering reservoir into the fill reservoir via the second one-way channel and expelling the fluid into the fill reservoir displaces air in the fill reservoir into the supply reservoir via the second flow path.

2. The fluid transfer device of claim 1, wherein the first one-way channel includes a first cannula and the second one-way channel includes a second cannula.

3. The fluid transfer device of claim 2, wherein the first cannula includes a beveled tip.

4. The fluid transfer device of claim 3, wherein the second cannula includes a beveled tip.

5. The fluid transfer device of claim 2, further comprising:

a member supporting the first and second cannulas, the first cannula extending in a first direction from the member and the second cannula extending in a second direction from the member, the first direction being generally opposite the second direction.

6. The fluid transfer device of claim 5, wherein the metering reservoir extends from the member generally in the first direction.

7. The fluid transfer device of claim 2 further comprising:

a manifold that supports the first and second cannulas, the manifold forming at least part of the first one-way channel and at least part of the second one-way channel.

8. The fluid transfer device of claim 2, wherein the first cannula has a larger cross sectional area than a cross sectional area of the second cannula.

9. The fluid transfer device of claim 1, further comprising:

a supply support configured to couple the fluid transfer device with the supply reservoir.

10. The fluid transfer device of claim 9, wherein the supply support includes at least one catch proximate the first channel and configured to releasably retain the supply reservoir.

11. The fluid transfer device of claim 10, wherein the at least one catch includes at least two catches spaced different distances from the first channel.

12. The fluid transfer device of claim 9, wherein the supply support includes at least one catch proximate the first channel and configured to non-releasably retain the supply reservoir.

13. The fluid transfer device of claim 9, wherein the supply support is configured to position the first one-way channel within the supply reservoir and the first one-way channel is configured to transfer substantially all of the fluid from the supply reservoir.

14. The fluid transfer device of claim 1, further comprising:

a member supporting the first and second one-way channels; and

a tray support connected to the member and configured to align the fill reservoir with the second one-way channel.

15. The fluid transfer device of claim 14, further comprising:

a tray slideably connected to the tray support and configured to accommodate the fill reservoir.

16. The fluid transfer device of claim 15, wherein at least one of the tray support and the tray further comprises a safety lock configured to prevent the tray from moving relative to a tray body when the tray is empty and exposing the second one-way channel.

17. The fluid transfer device of claim 15, further comprising:

a safety reservoir configured to removeably couple with the tray configured to block access to the second one-way channel in an initial position.

18. The fluid transfer device of claim 1, wherein the first one-way channel includes a first cannula, the second one-way channel includes a second cannula and the second flow path includes a third cannula.

19. The fluid transfer device of claim 18, wherein the third cannula is disposed within the first cannula and a first end of the third cannula is curved toward an inner side wall of the first cannula proximate a distal end of the first cannula.

20. The fluid transfer device of claim 18, wherein a second end of the third cannula comprises a beveled tip.

21. The fluid transfer device of claim 18, wherein the second and third cannula extend away from the metering reservoir, the second cannula extending further from the metering reservoir than the third cannula.

22. The fluid transfer device of claim 1, wherein the metering reservoir includes a plunger.

23. The fluid transfer device of claim 22, wherein the plunger comprises a plunger rod and a plunger tip.

24. The fluid transfer device of claim 1, wherein the metering reservoir has a metering stop.

25. The fluid transfer device of claim 24, wherein the metering stop is adjustable.

26. The fluid transfer device of claim 1, wherein the volume of the metering reservoir is larger than the volume of the fill reservoir.

27. The fluid transfer device of claim 26, wherein the volume of the supply reservoir is larger than the volume of the metering reservoir.

28. The fluid transfer device of claim 1, wherein the second flow path extends partially within the first one-way channel.

29. The fluid transfer device of claim 1, wherein a distal end of the first one-way channel and a first end of the second flow path are configured to sealingly engage with the supply reservoir and a distal end of the second one-way channel and a second end of the second flow path are each configured to sealingly engage with the fill reservoir.

30. The fluid transfer device of claim 1, wherein the first and second one-way channels each comprise less than 200 μ

l of fluid transfer space.

31. The fluid transfer device of claim 1, wherein a volume of the first one-way channel is less than a volume of the second one-way channel.

32. The fluid transfer device of claim 1, wherein the fill reservoir comprises a fluid delivery device and the supply reservoir comprises a vial.

33. The fluid transfer device of claim 1, wherein the second flow path is generally straight.

34. A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir, the fluid transfer device comprising:

a metering reservoir;

a first flow path having a first one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the supply reservoir and the metering reservoir and a second one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the fill reservoir and the metering reservoir;

a second flow path configured to fluidly couple the supply reservoir and the fill reservoir;

a member supporting the first and second one-way channels;

a tray support connected to the member and configured to align the fill reservoir with the second one-way channel; and

a tray slideably connected to the tray support and configured to accommodate the fill reservoir.

35. The fluid transfer device of claim 34, wherein at least one of the tray support and the tray further comprises a safety lock configured to prevent the tray from moving relative to a tray body when the tray is empty and exposing the second one-way channel.

36. The fluid transfer device of claim 34, further comprising:

a safety reservoir configured to removeably couple with the tray configured to block access to the second one-way channel in an initial position.

37. A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir, the fluid transfer device comprising:

a metering reservoir;

a first flow path having a first one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the supply reservoir and the metering reservoir and a second one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the fill reservoir and the metering reservoir; and

a second flow path configured to fluidly couple the supply reservoir and the fill reservoir;

wherein the first one-way channel includes a first cannula, the second one-way channel includes a second cannula and the second flow path includes a third cannula, and

wherein the third cannula is disposed within the first cannula and a first end of the third cannula is curved toward an inner side wall of the first cannula proximate a distal end of the first cannula.

38. The fluid transfer device of claim 37, wherein a second end of the third cannula comprises a beveled tip.

39. The fluid transfer device of claim 37, wherein the second and third cannula extend away from the metering reservoir, the second cannula extending further from the metering reservoir than the third cannula.