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GPR15-mediated homing and uses thereof

  • US 9,376,663 B2
  • Filed: 04/02/2014
  • Issued: 06/28/2016
  • Est. Priority Date: 04/02/2013
  • Status: Active Grant
First Claim
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1. A method for generating a population of CD4+CD3+CD25+T cells that migrates preferentially to the large intestine, the method comprising the steps of:

  • isolating a population of CD4+CD3+CD25+ T cells from a mammal; and

    incubating the population of CD4+CD3+CD25+ T cells in culture medium comprising TGF-β and

    IL-21 to produce a population of CD4+CD3+CD25+T cells having enhanced GPR15 expression, wherein the enhanced GPR15 expression confers on the population of CD4+CD3+CD25+T cells an ability to migrate preferentially to the large intestine.

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