Angle of incidence selective band pass filter for implantable chemical sensor

• US 9,377,351 B2
• Filed: 04/24/2013
• Issued: 06/28/2016
• Est. Priority Date: 04/24/2012
• Status: Expired due to Fees

• Current Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Original Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Inventors: Colvin, Arthur E. Jr.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/869,279
• Publication Number:
  US 20130324819A1
• Time in Patent Office: 1,161 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G01J 1/0214 Constructional arrangements for removing stray light
• CPC Class Codes: G01J 1/0425 using optical fibers
• CPC Class Codes: G01J 1/0488 with spectral filtering
• CPC Class Codes: G01J 1/06 Restricting the angle of incident light
• CPC Class Codes: G01J 1/1626 Arrangements with two photodetectors, the signals of which are compared
• CPC Class Codes: G01J 1/42 using electric radiation detectors optical or mechanical part G01J1/04; by comparison with a reference light or electric value G01J1/10
• CPC Class Codes: G01J 2001/062 by fibre-optic packed bundle
• CPC Class Codes: G01J 3/0218 using optical fibers
• CPC Class Codes: G01J 3/0262 Constructional arrangements for removing stray light
• CPC Class Codes: G01N 2021/6432 Quenching
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G02B 6/04 formed by bundles of fibres G02B6/24 takes precedence
• CPC Class Codes: G02B 6/08 with fibre bundle in form of plate

Abstract

Apparatuses and methods for limiting the angle of incidence (AOI) of light reaching a dichroic filter. The apparatus may include an AOI filter element and the dichroic filter. The apparatus may be a sensor and may include a photodetector. The dichroic filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass. Physical limitations of the dichroic filter may preclude the dichroic filter from preventing high AOI light having a wavelength outside a band pass region from reaching the photodetector. The AOI filter element may be configured to prevent light having a high AOI from reaching the dichroic band pass filter and to propagate light having a low AOI to the dichroic band pass filter. The AOI filter element may be a fiber optic bundle comprising a plurality of optical fibers.

Claims

1. A sensor comprising:

a sensor housing;

a graft on at least a portion of an exterior surface of the sensor housing;

indicator molecules distributed throughout the graft and configured to emit emission light at least to the receiving surface of the angle of incidence filter element;

a light source contained within the sensor housing and configured to irradiate excitation light to the indicator molecules;

a photodetector contained within the sensor housing and configured to convert received light into current indicative of the intensity of the received light;

a dichroic band pass filter contained within the sensor housing and configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass region to the photodetector; and

an angle of incidence filter element contained within the sensor housing, comprising a receiving surface, and configured to prevent light having an angle of incidence relative to an axis perpendicular to the receiving surface greater than a threshold angle from reaching the dichroic band pass filter and to propagate light having an angle of incidence relative to the axis perpendicular to the receiving surface less than the threshold angle to the dichroic band pass filter;

wherein the angle of incidence filter element is a fiber optic bundle comprising a plurality of optical fibers.

2. The sensor of claim 1, wherein each of the plurality of optical fibers comprises:

a core having a first refractive index; and

a clad having a second refractive index that is lower than the first refractive index;

wherein a relative value of the first and second refractive indices defines the threshold angle.

3. The sensor of claim 1, wherein the fiber optical bundle has been cut into a fiber optic plate.

4. The sensor of claim 1, wherein the indicator molecules are positioned relative to the receiving surface of the angle of incidence filter element such that at least a portion of the emission light reaches the receiving surface of the angle of incidence filter element with an angle of incidence relative to the axis perpendicular to the receiving surface less than the threshold angle.

5. The sensor of claim 1, wherein the dichroic band pass filter is a thin film dichroic band pass filter.

6. The sensor of claim 1, wherein the dichroic band pass filter is coated on the angle of incidence filter element.

7. The sensor of claim 6, wherein the angle of incidence filter element comprises an exit surface opposite the receiving surface, and the dichroic band pass filter is coated on the exit surface of the angle of incidence filter element.

8. The sensor of claim 1, wherein the dichroic band pass filter is coated on the photodetector.

9. The sensor of claim 1, wherein the photodetector is a photodiode.

10. The sensor of claim 1, wherein the threshold angle is less than or equal 25 degrees and greater than or equal to 5 degrees.

11. The sensor of claim 10, wherein the threshold angle is less than or equal to 20 degrees and greater than or equal to 10 degrees.

12. The sensor of claim 11, wherein the threshold angle is less than or equal to 17 degrees and greater than or equal to 12 degrees.

13. The sensor of claim 12, wherein the threshold angle is 15 degrees.

14. The sensor of claim 10, wherein the threshold angle is 10 degrees.

15. The sensor of claim 1, wherein the threshold angle is less than or equal to an angle of incidence relative to the axis perpendicular to the receiving surface of the angle of incidence filter element at which the spectral performance of the dichroic band pass filter begins to break down.

16. The sensor of claim 1, wherein the threshold angle is configured to optimize the optical signal to noise ratio (SNR) of the light received by the photodetector, analyte modulated light is the signal, and all other unwanted incident light is the noise.

17. The sensor of claim 1, wherein the photodetector is a first photodetector, the dichroic band pass filter is a first dichroic band pass filter, the band pass region is a first bandpass region, the receiving surface is a first receiving surface, the threshold angle is a first threshold angle, and the sensor comprises:

a second photodetector configured to convert received light into current indicative of the intensity of the light received by the second photodetector;

a second dichroic band pass filter configured to prevent light having a wavelength outside a second band pass region from reaching the second photodetector and to pass light having a wavelength within the second band pass region to the second photodetector; and

a second angle of incidence filter element comprising a second receiving surface and configured to prevent light having an angle of incidence relative to an axis perpendicular to the second receiving surface greater than a second threshold angle from reaching the second dichroic band pass filter and to propagate light having an angle of incidence relative to the axis perpendicular to the second receiving surface less than the second threshold angle to the second dichroic band pass filter.

18. The sensor of claim 1, wherein the sensor is a glucose sensor.

19. The sensor of claim 1, wherein the sensor is an oxygen sensor.

20. The sensor of claim 1, wherein the sensor is an implantable sensor configured for implantation into a living animal.

21. The sensor of claim 20, wherein the implantable sensor is configured for implantation into a living human.

22. A method of detecting the concentration of an analyte using a sensor comprising a sensor housing, a graft on at least a portion of an exterior surface of the sensor housing, a light source contained within the sensor housing, indicator molecules distributed throughout the graft, an angle of incidence filter element contained within the sensor housing, a dichroic band pass filter contained within the sensor housing, and a photodetector contained within the sensor housing;

the method comprising;

irradiating, by the light source, excitation light to the indicator molecules;

emitting, by the indicator molecules, emission light to the angle of incidence filter element;

receiving, by a receiving surface of the angle of incidence filter element, light including the emission light;

preventing, by the angle of incidence filter element, light of the received light having an angle of incidence greater than a threshold angle relative to an axis perpendicular to the receiving surface from reaching the dichroic band pass filter;

propagating, by the angle of incidence filter element, light of the received light having an angle of incidence less than the threshold angle relative to the axis perpendicular to the receiving surface;

preventing, by the dichroic band pass filter, light of the propagated light having a wavelength outside a band pass region of the dichroic band pass filter from reaching the photodetector;

passing, by the dichroic band pass filter, light of the propagated light having a wavelength within the band pass region of the dichroic band pass filter to the photodetector; and

receiving, by the photodetector, the passed light;

wherein the angle of incidence filter element is a fiber optic bundle comprising a plurality of optical fibers.

23. The method of claim 22, wherein each of the plurality of optical fibers comprises a core and a clad having refractive indices whose relative value defines the threshold angle.

24. The method of claim 22, wherein the fiber optical bundle has been cut into a fiber optic plate.

25. The method of claim 22, wherein at least a portion of the emission light reaches the receiving surface of the angle of incidence filter element with an angle of incidence relative to the axis perpendicular to the receiving surface less than the threshold angle.

26. The method of claim 22, wherein the threshold angle is less than or equal 20 degrees and greater than or equal to 5 degrees.

27. The method of claim 26, wherein the threshold angle is less than or equal to 20 degrees and greater than or equal to 10 degrees.

28. The method of claim 26, wherein the threshold angle is less than or equal to 17 degrees and greater than or equal to 12 degrees.

29. The method of claim 28, wherein the threshold angle is 15 degrees.

30. The method of claim 26, wherein the threshold angle is 10 degrees.

31. The method of claim 26, wherein the threshold angle is 20 degrees.

32. The method of claim 22, wherein the threshold angle is less than or equal to an angle of incidence relative to the axis perpendicular to the receiving surface of the angle of incidence filter element at which the spectral performance of the dichroic band pass filter begins to break down.

33. The method of claim 22, wherein the threshold angle is configured to optimize the optical signal to noise ratio (SNR) of the light received by the photodetector, analyte modulated light is the signal, and all other unwanted incident light is the noise.