Non-invasively monitoring blood parameters

• US 9,380,951 B2
• Filed: 02/04/2008
• Issued: 07/05/2016
• Est. Priority Date: 10/05/2004
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Henderson, Leslie G., Bailey, Theodore M.
• Primary Examiner(s): BERHANU, ETSUB D
• Application Number:
  US12/025,564
• Publication Number:
  US 20080132769A1
• Time in Patent Office: 3,074 Days
• Field of Search: 600/324, 600/325, 600/327, 600/332, 600/513
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

An apparatus for monitoring vital sign parameters in a biological entity is disclosed. In an embodiment, the apparatus includes at least one light source for transmitting light through the biological entity and at least one photodetector for receiving light transmitted through the biological entity. At least one light source and at least one photodetector are configured to be positioned proximate the biological entity in a manner that does not significantly impede blood flow through the biological entity. A signal is generated in response to the transmittance or reflectance of light through the biological entity. The signal corresponds to at least one characteristic of the generally unimpeded blood flow through the biological entity. The apparatus also includes a control system configured to analyze the signal to determine vital sign parameters in the biological entity. A method for monitoring vital sign parameters in a biological entity is also provided.

Claims

1. A system comprising:

a processor;

a sensor in communication with the processor, including;

at least one light source; and

at least one photodetector;

a display in communication with the processor;

an alarm in communication with the processor; and

a memory storing instructions executable by the processor for activating the alarm when a sensor response meets at least one predefined criterion;

the memory further storing instructions for periodically acquiring sensor responses, sampling the sensor responses at a sampling frequency to develop a waveform, developing a reference envelope having a lower limit band and an upper limit band wherein a proximity of the envelope to the waveform is based at least in part on the sampling frequency, and storing the envelope in the memory; and

wherein the at least one predefined criterion includes the photodetector response crossing the upper or lower limit of the envelope.

2. The system of claim 1, further comprising an electrocardiograph, the memory further storing instructions for acquiring and analyzing signals from the electrocardiograph.

3. The system of claim 2, the memory further storing instructions for comparing the acquired electrocardiograph signals with a sensor response, and identifying a heart condition of electromechanical disassociation by determining when the electrocardiograph signal represents electrical activity in the heart and the sensor response represents the absence of pumping action in the heart.

4. The system of claim 2, the memory further storing instructions for transmitting information from at least one of the sensor and the electrocardiograph to the display, determining at least one characteristic from the information wherein the characteristic is at least one of a blood parameter and a physiological marker, and displaying the characteristic in response to a request.

5. The system of claim 1, the memory further storing a record, wherein the record relates to at least one of a blood parameter and a physiological marker.

6. The system of claim 5, wherein the record is at least one of a previously-acquired record for a biological entity and a record representing a population, wherein the population is categorized by at least one of age, gender, height, weight, race, geographic residence, medical history, medical condition, education, military service, and occupation.

7. The system of claim 5, the memory further storing instructions for developing a set of characteristics from the sensor responses including at least one of a blood parameter and a physiological marker, comparing the set of characteristics to the record, determining a different blood parameter, and displaying at least one of the different blood parameter and a characteristic from the set of characteristics.

8. The system of claim 1, wherein the sensor is configured to be implanted into a biological entity.

9. The system of claim 1, wherein the sampling frequency is user-adjustable.

10. The system of claim 1, wherein the sensor comprises a pulse oximetry sensor for measuring blood oxygen saturation.

11. A method, comprising:

activating a light source that is included in a sensor positioned proximate a biological entity;

activating a photodetector that is included in the sensor;

acquiring a pulse waveform signal from the photodetector corresponding to a blood flow characteristic of the biological entity;

sampling the pulse waveform signal to obtain a second sampled signal;

identifying a peak value of the second sampled signal;

developing a reference envelope with a lower limit band and an upper limit band based at least in part on the peak value and a user input, and activating an alarm when an incoming signal from the photodetector crosses the upper or lower limit of the envelope.

12. The method of claim 11, further comprising periodically acquiring photodetector responses, developing a set of characteristics from the photodetector responses including at least one of a blood parameter and a physiological marker, comparing the set of characteristics to a record, determining a different blood parameter, and displaying at least one of the different blood parameter and a characteristic from the set of characteristics.

13. The method of claim 11, further comprising acquiring signals from an electrocardiograph, comparing the acquired electrocardiograph signals with the incoming signal, and identifying a heart condition of electromechanical disassociation when the electrocardiograph signal represents electrical activity in the heart and the photodetector response represents the absence of pumping action in the heart.

14. The method of claim 11, further comprising acquiring signals from an electrocardiograph, developing a set of characteristics from at least one of the pulse waveform signal and the electrocardiograph signal, and displaying at least one characteristic of the set of characteristics in response to a request.

15. The method of claim 11, wherein sampling the pulse waveform signal comprises sampling at a sampling rate, wherein developing the reference envelope comprises positioning the lower limit band and the upper limit band based at least in part on the sampling rate, and wherein the sampling rate is user-adjustable.

16. The method of claim 11, further comprising generating a database of reference envelope characteristics, and comparing the pulse waveform signal to the reference envelope characteristics in the database.

17. The method of claim 11, wherein the user input comprises a sampling frequency of the sampling of the pulse waveform signal.

18. The method of claim 11, wherein the user input comprises an amount of offset of the envelope.