High shear application in medical therapy

• US 9,381,138 B2
• Filed: 11/20/2013
• Issued: 07/05/2016
• Est. Priority Date: 04/30/2010
• Status: Active Grant

• Current Assignee: HRD Corporation
• Original Assignee: HRD Corporation
• Inventors: Hassan, Abbas, Hassan, Aziz, Anthony, Rayford G.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): CABRAL, ROBERT S
• Application Number:
  US14/085,420
• Publication Number:
  US 20140081198A1
• Time in Patent Office: 958 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 3/00 Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: B01F 27/2711 provided with intermeshing elements
• CPC Class Codes: B01F 27/272 with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
• CPC Class Codes: B01F 33/811 in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged

Abstract

In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Claims

1. A method comprising

mixing a therapeutic agent, nanodiamonds, and a liquid carrier in a high shear device to produce a dispersion, wherein the produced dispersion contains bubbles or droplets of said therapeutic agent with a mean diameter in the sub-nanometer range;

and

administering the produced dispersion intravenously to a patient.

2. The method of claim 1 wherein the high shear device comprises at least one rotor and at least one complementarily-shaped stator.

3. The method of claim 2 wherein the high shear device is operated to provide a shear rate of greater than about 20,000 s⁻

1.

4. The method of claim 1 wherein the produced dispersion comprises a cancer therapeutic.

5. The method of claim 4 wherein the produced dispersion comprises doxorubicin.

6. The method of claim 1 wherein the produced dispersion comprises curcumin.