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SHK-based pharmaceutical compositions and methods of manufacturing and using the same

  • US 9,381,261 B2
  • Filed: 06/05/2012
  • Issued: 07/05/2016
  • Est. Priority Date: 06/06/2011
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising a pharmaceutically acceptable salt of an ShK polypeptide having the sequence of SEQ ID NO:

  • 1 or SEQ ID NO;

    2, wherein the ShK polypeptide is attached to an organic or inorganic chemical entity that has an anionic charge, and the C-terminus is an acid or an amide, wherein the pH of the pharmaceutical composition is between 5 and 7 and the pharmaceutical composition further comprises a surfactant in an amount effective to dissolve the ShK polypeptide in an aqueous carrier.

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