Embolic devices

• US 9,381,278 B2
• Filed: 03/18/2015
• Issued: 07/05/2016
• Est. Priority Date: 04/18/2012
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Constant, Michael, Keeley, Edward Michael, Garretson, Joshua, Cruise, Gregory M.
• Primary Examiner(s): ROGERS, JAMES WILLIAM
• Application Number:
  US14/661,995
• Publication Number:
  US 20150190553A1
• Time in Patent Office: 475 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 47/30 Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 49/0404 containing barium sulfate
• CPC Class Codes: A61K 49/126 Linear polymers, e.g. dextran, inulin, PEG
• CPC Class Codes: A61K 51/1213 Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: Y10T 428/298 Physical dimension

Abstract

Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.

Claims

1. A hydrogel for implantation comprising:

a polymeric filament formed from a combination of precursors comprising an ethoxylated trimethylol propane macromer and at least one ethylenically unsaturated monomer, wherein the ethoxylated trimethylol propane macromer is trimethylolpropane ethoxylate triacrylamide.

2. The hydrogel according to claim 1, wherein the combination of precursors further comprises at least one visualization agent selected from metallic powders, gadolinium, superparamagnetic iron oxide particles, iodine, barium sulfate or a combination thereof.

3. The hydrogel according to claim 1, wherein the at least one ethylenically unsaturated monomer includes iodine.

4. The hydrogel according to claim 1, wherein the polymeric filament has a diameter of less than about 0.03 inches.

5. The hydrogel according to claim 1, wherein the at least one ethylenically unsaturated monomer is t-butyl acrylamide, hydroxyethyl methacrylate, or a combination thereof.

6. The hydrogel according to claim 1, wherein the trimethylolpropane ethoxylate triacrylamide has a molecular weight of about 900 g/mole.

7. The hydrogel according to claim 1, wherein the combination of precursors further comprises a cross-linker.

8. The hydrogel according to claim 1, wherein the hydrogel includes no metal support members.

9. The hydrogel according to claim 1, wherein the polymeric filament is non-resorbable after implantation.

10. The hydrogel according to claim 1, wherein the polymeric filament is biodegradable.