Implantable devices formed on non-fouling methacrylate or acrylate polymers

• US 9,381,279 B2
• Filed: 04/19/2010
• Issued: 07/05/2016
• Est. Priority Date: 03/24/2005
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Pacetti, Stephen D.
• Primary Examiner(s): Kwon, Brian-Yong
• Assistant Examiner(s): BECKHARDT, LYNDSEY MARIE
• Application Number:
  US12/763,113
• Publication Number:
  US 20100266659A1
• Time in Patent Office: 2,269 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 33/064 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen

Abstract

Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Claims

1. An stent having a coating comprising a polymer that comprises repeating units of Formula I:

2. The stent of claim 1,

wherein:

X is absent.

3. The stent of claim 1,

wherein:

X is O.

4. The stent of claim 1,

wherein:

X is S.

5. The stent of claim 1,

wherein:

X is NR₇.

6. The stent of claim 1,

wherein:

R₃, R₄, and R₅ are independently H, CH₃, ethyl, propyl, isopropyl, isobutyl, sec-butyl, n-butyl, or phenyl, silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(alkylene oxide).

7. The stent of claim 1,

wherein:

R₃, and R₄ are independently H and CH₃; and

R₅ is silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(alkylene oxide).

8. The stent of claim 1, further comprising a bioactive agent.

9. The stent of claim 8, wherein the bioactive agent is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, ABT-578, clobetasol, prodrugs thereof, co-drugs thereof, and a combination thereof.

10. A method of fabricating a stent, comprising forming on the stent a coating according to claim 1.

11. A method of treating a disorder in a patient comprising implanting in the patient the implantable device of claim 1, wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.