Implantable drug delivery devices

• US 9,381,299 B2
• Filed: 12/02/2013
• Issued: 07/05/2016
• Est. Priority Date: 02/17/2009
• Status: Active Grant

• Current Assignee: Kuvio, Inc.
• Original Assignee: Kuvio, Inc.
• Inventors: Kuo, Youti, Violante, Michael R.
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US14/093,915
• Publication Number:
  US 20140142556A1
• Time in Patent Office: 946 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/067 Flexible ampoules, the contents of which are expelled by squeezing
• CPC Class Codes: A61J 1/14 Details; Accessories therefor A61J7/00 takes precedence; openers B65D, B67B7/00
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2039/0238 having means for locating the implanted device to insure proper injection, e.g. radio-emitter, protuberances, radio-opaque markers
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3389 Continuous level detection A61M2205/3393 takes precedence
• CPC Class Codes: A61M 2205/3515 using magnetic means
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/70 with testing or calibration facilities
• CPC Class Codes: A61M 2209/045 for filling, e.g. for filling reservoirs
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/168 Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body flow control in general G05D7/00

Abstract

The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers.

Claims

1. A refill container for refilling an implantable drug delivery device comprising:

a. a tubular housing with inner wall surface having first opening and second opening, said tubular housing containing a drug fluid,

b. a needle being attached to the second opening, said needle being in flow communication with the tubular housing,

c. a disc situated inside said tubular housing in slidable sealing fit with an inner wall surface, said disc not accessible from outside the housing and being only movable following the flow direction toward the needle when the drug fluid is being removed from the housing through the needle, said disc being exposed to ambient pressure through the first opening.

2. The refill container according to claim 1, wherein said

tubular housing comprises a valve chamber situated at said second opening end and a reservoir chamber situated at said first opening end, and further comprising

an orifice plate being positioned separating the valve chamber and the reservoir chamber, said orifice plate having an orifice at the center for passing a drug fluid from the reservoir chamber to the valve chamber, and said valve chamber includes

a movable magnet valve having a polarity being situated in said valve chamber such that said magnet valve blocks the opening of the orifice plate when moved in contact with the orifice plate and allows for the flow of the drug fluid from the reservoir chamber to the needle when said magnet valve is moved away from the orifice plate.

3. A refill system of an implantable dual drug delivery device comprising:

a. a first refill container containing a first drug fluid having a magnet valve with a first polarity,

b. a second refill container containing a second drug fluid having a magnet valve with a second polarity,

c. a first drug chamber containing a first drug fluid and having an outlet, a septum and a first piston, said septum being attached with a first magnet with first polarity attracting the magnet valve of the first refill container and repelling the magnet valve of the second refill container,

d. a second drug chamber containing a second drug fluid and having an outlet, a septum and a second piston, said septum being attached with a second magnet with second polarity attracting the magnet valve of the second refill container, said second polarity being opposite to the first polarity of said first refill container.